Role of TRP channels in carcinogenesis and metastasis: Pathophysiology and regulation by non-coding RNAs
Turgambayeva A. Duisekova S. Tashenova G. Tulebayeva A. Kapanova G. Akhenbekova A. Farooqi A.A.
June 2024KeAi Communications Co.
Non-coding RNA Research
2024#9Issue 2359 - 366 pp.
In 2021, David Julius and Ardem Patapoutian received Nobel Prize in Physiology or Medicine for their ground-breaking discoveries in the functional characterization of receptors for temperature and touch. Transient receptor potential (TRP) channels have captivated tremendous appreciation as promising drug targets over the past few years because of central involvement in different cancers. Based on the insights gleaned from decades of high-quality research, basic and clinical scientists have unveiled how Transient receptor potential channels regulated cancer onset and progression. Pioneering studies have sparked renewed interest and researchers have started to scratch the surface of mechanistic role of these channels in wide variety of cancers. In this review we have attempted to provide a summary of most recent updates and advancements made in the biology of these channels in context of cancers. We have partitioned this review into different subsections on the basis of emerging evidence about characteristically distinct role of TRPV (TRPV1, TRPV5), TRPM (TRPM3, TRPM7) and TRPC in cancers. Regulation of TRP channels by non-coding RNAs is also a very exciting area of research which will be helpful in developing a sharper understanding of the multi-step aspects of cancers.
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Department Public Health and Management, NJSC, Astana Medical University, Astana, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Al-Farabi Kazakh National University, 71 Al-Farabi Ave, Almaty, 050040, Kazakhstan
Scientific Center of Anti-Infectious Drugs, 75 Al-Farabi Ave, Almaty, 050040, Kazakhstan
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan
Department Public Health and Management
Asfendiyarov Kazakh National Medical University
Al-Farabi Kazakh National University
Scientific Center of Anti-Infectious Drugs
Institute of Biomedical and Genetic Engineering (IBGE)
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