Biochemical parameters of rat blood during cadmium intoxication and subsequent correction with Tagansorbent
Tungushbaeva Z.B. Kozhakhmetova A.Zh. Tussupova N. Bakesova R.M. Kunakbayev A. Dyusembaieva A.T. Zhazira Z.
2025University of Guilan
Caspian Journal of Environmental Sciences
2025#23Issue 51209 - 1216 pp.
The aim of this research was to investigate the protective effects of Tagansorbent on cadmium poisoning-induced biochemical disorders in rats. In this experimental study, 40 rats were divided into four groups and received treatment for 14 days. The results showed that cadmium poisoning highly significantly increased liver enzymes, including ALT, AST, and ALP. Renal function indices also revealed significant increases, including urea and creatinine. All these parameters were significantly improved in the group treated with Tagansorbent along with cadmium. Besides, Tagansorbent significantly reduced the level of malondialdehyde and increased the total antioxidant capacity in the liver tissue (p < 0.01). The findings of the current study demonstrated that Tagansorbent could reduce the toxic effects of this element on the liver and kidney through multiple mechanisms such as cadmium absorption and reduction of oxidative stress, and thus can be considered as an auxiliary agent in the management of cadmium poisoning.
Cadmium , Hepatorenal toxicity , Oxidative stress , Tagansorbent
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Department of Biology, Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan
Kazakh-Russian Medical University, Almaty, Kazakhstan
Medical center Talmas Medicus, Astana, Kazakhstan
Department of Anatomy with courses, Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Physical Culture and Informatics, Institute of education and management, West Kazakhstan Innovative Technological University, Uralsk, Kazakhstan
Kazakh-Russian Medical University, Almaty, Kazakhstan
Department of Biology
Kazakh-Russian Medical University
Medical center Talmas Medicus
Department of Anatomy with courses
Department of Physical Culture and Informatics
Kazakh-Russian Medical University
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