Characterisation of Orthohantavirus Serotypes in Human Infections in Kazakhstan
Tukhanova N. Shin A. Bakuli A. Yeraliyeva L. Maikanov N. Froeschl G. Zhumadilova Z. Tokmurziyeva G. Wagner E. Essbauer S. Peintner L.
July 2025Multidisciplinary Digital Publishing Institute (MDPI)
Viruses
2025#17Issue 7
Orthohantavirus infection is a zoonotic disease transmitted to humans through contact with infected rodents. In Eurasia, Old World Orthohantaviruses can cause haemorrhagic fever with renal syndrome (HFRS), while in the Americas, New World Orthohantaviruses are responsible for hantavirus cardiopulmonary syndrome (HCPS). In Kazakhstan, the first recorded cases of HFRS appeared in the West Kazakhstan region in 2000, which has since then been established as an endemic area due to the presence of stable rodent reservoirs and recurring human infections. Routine diagnosis of HFRS in this region relies primarily on immunoassays. To enhance diagnostic precision, we aimed to implement both serological and molecular methods on samples from suspected HFRS cases in the endemic West Kazakhstan region and non-endemic Almaty City. A total of 139 paired serum, saliva, and urine samples were analysed using IgM/IgG ELISA, immunoblot assays, and qPCR. Our findings confirm that suspected HFRS cases in West Kazakhstan are associated with the Puumala virus serotype.
human infections , Kazakhstan , orthohantavirus , serology
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M. Aikimbayev’s National Scientific Center of Especially Dangerous Infections, Almaty, 050054, Kazakhstan
Department of Infectious and Tropical Disease, S. Asfendiyarov Kazakh National Medical University, Almaty, 050012, Kazakhstan
Department of General Medical Practice, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Division of Infectious Diseases and Tropical Medicine, University Hospital, Ludwig-Maximilians-University, Munich, 80802, Germany
National Scientific Center of Phthisiopulmonology, Almaty, 050010, Kazakhstan
Oral Antiplague Station, Oral, 090001, Kazakhstan
Institute of Medical Microbiology, Jena University Hospital, Jena, 07747, Germany
Department of Virology and Intracellular Agents, Bundeswehr Institute of Microbiology, Munich, 80937, Germany
Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg im Breisgau, 79104, Germany
M. Aikimbayev’s National Scientific Center of Especially Dangerous Infections
Department of Infectious and Tropical Disease
Department of General Medical Practice
Division of Infectious Diseases and Tropical Medicine
National Scientific Center of Phthisiopulmonology
Oral Antiplague Station
Institute of Medical Microbiology
Department of Virology and Intracellular Agents
Institute of Molecular Medicine and Cell Research
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