Importance of the pneumococcus in community-acquired pneumonia in tender-age infants on the background of vaccination
Tukbekova B.T. Zhanpeissova A.A. Akhmetova S.B. Sandugash B.D. Alimshaikhina K.Zh. Sarmankulova G.A.
2021Scientific Foundation SPIROSKI
Open Access Macedonian Journal of Medical Sciences
2021#9Issue B1525 - 1528 pp.
AIM: The aim of the study was to study the role of pneumococcus in community-acquired pneumonia in young tender-age infants on the background of vaccination. MATERIALS AND METHODS: In this research, 82 children with community-acquired pneumonia we examined. They were treated at the Regional Children’s Clinical Hospital of the Karaganda city. The age of the patients ranged from 2 months up to 3 years. A comprehensive examination of the patients was carried out and included a detailed collection of anamnesis, objective examination, laboratory studies, and methods of instrumental diagnostics. The patients were divided into two groups, the first group included 42 (51.2%) vaccinated children with community-acquired pneumonia. The second one included 40 (48.8%) children with impaired immunization to community-acquired pneumonia. Calculations and evaluation of the obtained results were carried out on an IBM-compatible computer with the operating system Windows XP using the MS Excel 2017 software package (Microsoft), SPSS 12.0.2 and Statistica 20. Statistical analysis was carried out using the STATISTICA package. Relative frequency of occurrence of the trait in different groups (proportion) p was determined by the confidence interval statistically significant differences were considered at p < 0.05. RESULTS: Our research revealed that the etiological structure of CAP in vaccinated children is represented by pathogenic strains of Streptococci, Streptococcus pyogenes were more often detected and Streptococcus beta-hemolytic Group B was detected less often. The Staphylococcus family was represented with such pathogenic strains as: Staphylococcus aureus, and less 01)-Staphylococcus haemolyticus. Gram-negative flora was mainly represented by Haemophilus influenzae, Mycoplasma pneumoniae, Escherichia coli, Klebsiella pneumoniae, less often Enterobacter aerogenes, and Klebsiella oxytoca. The etiological structure of CAP in young children was characterized by the predominance (62.5%, p < 0.001) of Gram-positive flora in the group of children with impaired immunization. Significant differences are found between groups of children. Therefore, in vaccinated children, concurrent infection was prevailed (42.9%). And in the group of infants with impaired immunization was detected Streptococcus pneumoniae (37.5%). Aforecited indicates the effect of pneumococcal vaccination on the etiological structure of CAP in tender-age infants. CONCLUSION: Thus, the applied microbiological research methods make it possible to improve the efficiency of timely diagnosis of community-acquired pneumonia in vaccinated infants with pneumococcal vaccine at the stationary level, to improve the individual prognosis of the disease course.
Streptococcus pneumoniae , Structure of pneumonia , Vaccination
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Department of Pediatrics and Neonatology, NJSC “Medical University of Karaganda,” Karaganda Medical University, Karaganda City, Kazakhstan
Department of Biomedicine, NJSC “Medical University of Karaganda,” Karaganda Medical University, Karaganda City, Kazakhstan
Department of Pediatrics and Neonatology
Department of Biomedicine
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