Ag3PO4-based composites as next-generation antibacterial nanomaterials: A review of light induced synergistic effects


Tugelbay S. Yergaliuly G. Abilkhan A. Khan N. Tatykayev B.
15 October 2025Elsevier B.V.

Chemical Engineering Journal
2025#522

The rising threat of multidrug-resistant (MDR) pathogens necessitates innovative, light-responsive antimicrobial strategies. Silver phosphate (Ag3PO4) with its unique dual-functionality-simultaneous Ag+ ion release and visible-light-induced reactive oxygen species (ROS) generation-has emerged as a potent antibacterial agent. This review provides a comprehensive analysis of Ag3PO4-based nanocomposites, emphasizing how structural tuning, bandgap engineering, and nanoscale morphology influence antimicrobial activity. Binary (Ag3PO4/TiO2, Ag3PO4/X) and ternary (Ag3PO4/X/X) heterostructures have been investigated to overcome key limitations, including photocorrosion, while enabling spatially controlled ROS generation and regulated Ag+ release across the visible and near-infrared (NIR) spectrum. Mechanistic insights into differential inactivation of Gram-positive, Gram-negative, and fungal pathogens are discussed, with a focus on nanostructure-mediated oxidative and ionic stress responses. Additionally, advanced strategies including doping, defect modulation, and interfacial design are explored to enhance charge separation, durability, and biological compatibility. By unifying current progress and critical knowledge gaps, this review highlights Ag3PO4 as a next-generation antimicrobial platform with high potential for clinical, environmental, and industrial applications.

Ag3PO4 , Antibacterial activity , Antibacterial mechanism , Photocatalysts , Photocatalytic activity , Reactive oxygen species

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Department of General and Inorganic Chemistry, Al-Farabi Kazakh National University, Al-Farabi Ave., 71, Almaty, 050040, Kazakhstan
National Laboratory Astana, Nazarbayev University, Kabanbay Batyr Ave., 53, Astana, 010000, Kazakhstan

Department of General and Inorganic Chemistry
National Laboratory Astana

10 лет помогаем публиковать статьи Международный издатель

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