Akt: a key transducer in cancer
Tsai P.-J. Lai Y.-H. Manne R.K. Tsai Y.-S. Sarbassov D. Lin H.-K.
December 2022BioMed Central Ltd
Journal of Biomedical Science
2022#29Issue 1
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its deregulation has been linked to various human diseases. Akt kinase is a central player transmitting extracellular clues to various cellular compartments, in turn executing these biological processes. Since the discovery of Akt three decades ago, the tremendous progress towards identifying its upstream regulators and downstream effectors and its roles in cancer has been made, offering novel paradigms and therapeutic strategies for targeting human diseases and cancers with deregulated Akt activation. Unraveling the molecular mechanisms for Akt signaling networks paves the way for developing selective inhibitors targeting Akt and its signaling regulation for the management of human diseases including cancer.
Akt , Cancer , PI3K , Posttranslational modifications , Skp2 , TRAF6
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Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, 27157, NC, United States
Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Biology Department, School of Sciences and Humanities, and National Laboratory Astana, Nazarbayev University, Nur-Sultan City, 010000, Kazakhstan
Department of Cancer Biology
Department of Medical Laboratory Science and Biotechnology
Institute of Basic Medical Sciences
Institute of Clinical Medicine
Biology Department
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