New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties
Trifonov A.V. Appazov N.O. Bagautdinova R.K. Kibardina L.K. Pudovik M.A. Lyubina A.P. Voloshina A.D. Gazizov A.S. Tolegen A.E. Togyzbayeva N.A. Syzdykbayev M.I. Turmanov R.A. Diyarova B.M. Chugunova E.A. Burilov A.R.
August 2025Pleiades Publishing
Russian Journal of General Chemistry
2025#95Issue 82192 - 2199 pp.
Abstract: As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.
antitumor agent , coumarin , cytotoxicity , furopyridine , Meldrum’s acid
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Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088, Russian Federation
Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
“CNEC” LLP, Kyzylorda, 120001, Kazakhstan
Department of Oil, Chemistry and Nanotechnology, Kazan National Research Technological University, Kazan, 420015, Russian Federation
“DPS Kyzylorda” LLP, Kyzylorda, 120008, Kazakhstan
Kazakh National Women’s Teacher Training University, Almaty, 050000, Kazakhstan
Arbuzov Institute of Organic and Physical Chemistry
Korkyt Ata Kyzylorda University
“CNEC” LLP
Department of Oil
“DPS Kyzylorda” LLP
Kazakh National Women’s Teacher Training University
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