New 7-azacoumarin-3-carboxamide phosphonium salts: cytotoxicity and the Wittig olefination
Trifonov A.V. Appazov N.O. Bagautdinova R.K. Kibardina L.K. Pudovik M.A. Lyubina A.P. Voloshina A.D. Gazizov A.S. Tolegen A.E. Togyzbayeva N.A. Darmagambet K.Kh. Turmanov R.A. Chugunova E.A. Burilov A.R.
2025Mendeleevskie Soobshcheniya
Mendeleev Communications
2025#35Issue 5537 - 539 pp.
New phosphonium salts synthesized from 5-chloromethyl-8-methyl-7-azacoumarin-3-carboxamides and triphenyl-phosphine upon the Wittig reaction with aromatic aldehydes give the corresponding 5-styryl-7-azacoumarin derivatives. The cytotoxic activity of some phosphonium salts against cancer cell lines M-HeLa and HuTu-80 is equal to or superior to that of the reference 5-fluorouracil. The IC50 and SI values of the leading compounds exceed those for 5-fluorouracil by a factor of 3.7 and 2.2, respectively.
azacoumarin , carboxamides , cytotoxicity , triphenylphosphonium salts , Wittig reaction
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A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, 420088, Russian Federation
Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
‘CNEC’ LLP, Kyzylorda, 120001, Kazakhstan
Department of Oil, Chemistry and Nanotechnology, Kazan National Research Technological University, Kazan, 420015, Russian Federation
‘DPS Kyzylorda’ LLP, Kyzylorda, 120008, Kazakhstan
A. E. Arbuzov Institute of Organic and Physical Chemistry
Korkyt Ata Kyzylorda University
‘CNEC’ LLP
Department of Oil
‘DPS Kyzylorda’ LLP
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