Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
Towns C. Richer M. Jasaityte S. Stafford E.J. Joubert J. Antar T. Martinez-Carrasco A. Makarious M.B. Casey B. Vitale D. Levine K. Leonard H. Pantazis C.B. Screven L.A. Hernandez D.G. Wegel C.E. Solle J. Nalls M.A. Blauwendraat C. Singleton A.B. Tan M.M.X. Iwaki H. Morris H.R. Gatto E.M. Kauffman M. Khachatryan S. Tavadyan Z. Shepherd C.E. Hunter J. Kumar K. Ellis M. Rentería M.E. Koks S. Zimprich A. Schumacher-Schuh A.F. Rieder C. Awad P.S. Tumas V. Camargos S. Fon E.A. Monchi O. Fon T. Galleguillos B.P. Miranda M. Bustamante M.L. Olguin P. Chana P. Tang B. Shang H. Guo J. Chan P. Luo W. Arboleda G. Orozco J. del Rio M.J. Hernandez A. Salama M. Kamel W.A. Zewde Y.Z. Brice A. Corvol J.-C. Westenberger A. Illarionova A. Mollenhauer B. Klein C. Vollstedt E.-J. Hopfner F. Höglinger G. Madoev H. Trinh J. Junker J. Lohmann K. Lange L.M. Sharma M. Groppa S. Gasser T. Fang Z.-H. Akpalu A. Xiromerisiou G. Hadjigorgiou G. Dagklis I. Tarnanas I. Stefanis L. Stamelou M. Dadiotis E. Medina A. Chan G.H.-F. Ip N. Cheung N.Y.-F. Chan P. Zhou X. Kishore A. Kp D. Pal P. Kukkle P.L. Rajan R. Borgohain R. Salari M. Quattrone A. Valente E.M. Parnetti L. Avenali M. Schirinzi T. Funayama M. Hattori N. Shiraishi T. Karimova A. Kaishibayeva G. Shambetova C. Krüger R. Tan A.H. Ahmad-Annuar A. Norlinah M.I. Murad N.A.A. Azmin S. Lim S.-Y. Mohamed W. Tay Y.W. Martinez-Ramirez D. Rodriguez-Violante M. Reyes-Pérez P. Tserensodnom B. Ojha R. Anderson T.J. Pitcher T.L. Sanyaolu A. Okubadejo N. Ojo O. Aasly J.O. Pihlstrøm L. Ur-Rehman S. Cornejo-Olivas M. Doquenia M.L. Rosales R. Vinuela A. Iakovenko E. Mubarak B.A. Umair M. Tan E.-K. Foo J.N. Amod F. Carr J. Bardien S. Jeon B. Kim Y.J. Cubo E. Alvarez I. Hoenicka J. Beyer K. Periñan M.T. Pastor P. El-Sadig S. Zweier C. Krack P. Lin C.-H. Wu H.-C. Kung P.-J. Wu R.-M. Wu Y. Amouri R. Sassi S.B. Başak A.N. Genc G. Çakmak Ö.Ö. Ertan S. Noyce A. Schrag A. Schapira A. Carroll C. Bale C. Grosset D. Houlden H. Hardy J. Mok K.Y. Rizig M. Wood N. Williams N. Okunoye O. Lewis P.A. Kaiyrzhanov R. Weil R. Love S. Stott S. Jasaitye S. Dey S. Obese V. Espay A. O’Grady A. Sobering A.K. Siddiqi B. Fiske B. Jonas C. Cruchaga C. Comart C. Hall D. Shiamim E. Riley E. Faghri F. Serrano G.E. Chen H. Mata I.F. Sarmiento I.J.K. Williamson J. Kim J.J. Jankovic J. Shulman J. Murphy K. Nuytemans K. Kieburtz K. Markopoulou K. Marek K. Chahine L.M. Ibanez L. Ruffrage L. Shulman L. Marsili L. Kuhl M. Dean M. Koretsky M. Puckelwartz M.J. Inca-Martinez M. Louie N. Mencacci N.E. Albin R. Alcalay R. Walker R. Bandres-Ciga S. Chowdhury S. Dumanis S. Lubbe S. Xie T. Foroud T. Beach T. Sherer T. Song Y. Nguyen D. Nguyen T. Atadzhanov M.
December 2023Nature Research
npj Parkinsons Disease
2023#9Issue 1
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
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Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, United Kingdom
University College London, London, United Kingdom
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States
National Institutes of Health, Bethesda, MD, United States
Department of Clinical Research, Michael J. Fox Foundation for Parkinson’s Research, New York City, NY, United States
The Michael J. Fox Foundation for Parkinson’s Research, New York, NY, United States
Center for Alzheimer’s and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
Data Tecnica International, Washington, DC, United States
National Institute on Aging/National Institutes of Health, Bethesda, MD, United States
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States
Integrative Genomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States
National Institute on Aging, Bethesda, MD, United States
Department of Neurology, Oslo University Hospital, Oslo, Norway
Sanatorio de la Trinidad Mitre- INEBA, Buenos Aires, Argentina
Hospital JM Ramos Mejia, Buenos Aires, Argentina
Somnus Neurology Clinic, Yerevan, Armenia
Neuroscience Research Australia, Sydney, NSW, Australia
ANZAC Research Institute, Concord, NSW, Australia
Garvan Institute of Medical Research and Concord Repatriation General Hospital, Darlinghurst, NSW, Australia
Concord Hospital, Concord, NSW, Australia
QIMR Berghofer Medical Research Institute, Herston, QLD, Australia
Murdoch University, Perth, Australia
Medical University Vienna Austria, Vienna, Austria
Universidade Federal do Rio Grande do Sul / Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil
Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
University of São Paulo, São Paulo, Brazil
Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Montreal Neurological Institute, Montreal, QC, Canada
Institut universitaire de gériatrie de Montréal, Montreal, QC, Canada
McGill University, Montreal, QC, Canada
Universidad de Chile, Santiago, Chile
Fundación Diagnosis, Santiago, Chile
Faculty of Medicine Universidad de Chile, Santiago, Chile
CETRAM, Santiago, Chile
Central South University, Changsha, China
West China Hospital Sichuan University, Chengdu, China
Xiangya Hospital, Changsha, China
Capital Medical University, Beijing, China
Zhejiang University, Hangzhou, China
Universidad Nacional de Colombia, Bogotá, Colombia
Fundación Valle del Lili, Santiago De Cali, Colombia
University of Antioquia, Medellin, Colombia
University of Costa Rica, San Jose, Costa Rica
The American University in Cairo, Cairo, Egypt
Beni-Suef University, Beni Suef, Egypt
Addis Ababa University, Addis Ababa, Ethiopia
Paris Brain Institute, Paris, France
Sorbonne Université, Paris, France
University of Lübeck, Lübeck, Germany
Deutsches Zentrum für Neurodegenerative Erkrankungen, Göttingen, Germany
University Medical Center Göttingen, Göttingen, Germany
Department of Neurology, University Hospital, LMU Munich, Munich, Germany
University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany
University of Tubingen, Tübingen, Germany
University of Mainz, Mainz, Germany
The German Center for Neurodegenerative Diseases, Göttingen, Germany
University of Ghana Medical School, Accra, Ghana
University of Thessaly, Volos, Greece
Aristotle University of Thessaloniki, Thessaloniki, Greece
Ionian University, Corfu, Greece
Biomedical research Foundation of the Academy of Athens, Athens, Greece
Diagnostic and Therapeutic Centre HYGEIA Hospital, Marousi, Greece
Hospital San Felipe, Tegucigalpa, Honduras
Queen Elizabeth Hospital, Kowloon, Hong Kong
The Hong Kong University of Science and Technology, Kowloon, Hong Kong
Aster Medcity, Kochi, India
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
National Institute of Mental Health & Neurosciences, Bengaluru, India
Manipal Hospital, Delhi, India
All India Institute of Medical Sciences, Delhi, India
Nizam’s Institute Of Medical Sciences, Hyderabad, India
Shahid Beheshti University of Medical Science, Tehran, Iran
Magna Græcia University of Catanzaro, Catanzaro, Italy
University of Pavia, Pavia, Italy
University of Perugia, Perugia, Italy
University of Rome Tor Vergata, Rome, Italy
Juntendo University, Tokyo, Japan
Juntendo University faculty of medicine, Tokyo, Japan
Jikei University School of Medicine, Tokyo, Japan
Institute of Neurology and Neurorehabilitation, Almaty, Kazakhstan
Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
University of Luxembourg, Luxembourg, Luxembourg
University of Malaya, Kuala Lumpur, Malaysia
Universiti Kebangsaan Malaysia, Selangor, Malaysia
UKM Medical Molecular Biology Institute, Kuala Lumpur, Malaysia
Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
International Islamic University, Kuala Lumpur, Malaysia
Tecnologico de Monterrey, Monterrey, Mexico
Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico
Universidad Nacional Autónoma de México, Mexico City, Mexico
Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia
Tribhuvan University, Kirtipur, Nepal
University of Otago, Dunedin, New Zealand
University of Lagos, Lagos, Nigeria
College of Medicine of the University of Lagos, Lagos, Nigeria
Norwegian University of Science and Technology, Trondheim, Norway
Oslo University Hospital, Oslo, Norway
University of Science and Technology Bannu, Bannu, Pakistan
Universidad Cientifica del Sur, Lima, Peru
Metropolitan Medical Center, Manila, Philippines
University of Puerto Rico, San Juan, Puerto Rico
Research Center of Neurology, Moscow, Russian Federation
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
King Abdullah International Medical Research Center, Jeddah, Saudi Arabia
National Neuroscience Institute, Singapore, Singapore
Nanyang Technological University, Singapore, Singapore
University of KwaZulu-Natal, Durban, South Africa
University of Stellenbosch, Stellenbosch, South Africa
Stellenbosch University, Stellenbosch, South Africa
Seoul National University Hospital, Seoul, South Korea
Yongin Severance Hospital, Seoul, South Korea
Hospital Universitario Burgos, Burgos, Spain
University Hospital Mutua Terrassa, Barcelona, Spain
Institut de Recerca Sant Joan de Deu, Barcelona, Spain
Research Institute Germans Trias i Pujol, Barcelona, Spain
Instituto de Biomedicina de Sevilla, Seville, Spain
University Hospital Germans Trias i Pujol, Barcelona, Spain
Faculty of medicine university of Khartoum, Khartoum, Sudan
Inselspital Bern, University of Bern, Bern, Switzerland
National Taiwan University Hospital, Taipei City, Taiwan
Chang Gung Memorial Hospital, Taoyuan City, Taiwan
National Taiwan University, Taipei City, Taiwan
National Institute Mongi Ben Hamida of Neurology, Tunis, Tunisia
Mongi Ben Hmida National Institute of Neurology, Tunis, Tunisia
Koç University, Istanbul, Turkey
Sisli Etfal Training and Research Hospital, Istanbul, Turkey
Queen Mary University of London, London, United Kingdom
University of Plymouth, Plymouth, United Kingdom
Parkinson’s UK, London, United Kingdom
University of Glasgow, Glasgow, United Kingdom
Cardiff University, Cardiff, United Kingdom
Royal Veterinary College University of London, London, United Kingdom
University of Bristol, Bristol, United Kingdom
Cure Parkinson’s, London, United Kingdom
University of Cincinnati, Cincinnati, OH, United States
Augusta University / University of Georgia Medical Partnership, Augusta, GA, United States
Mid-Atlantic Permanente Medical Group, Bethesda, MD, United States
Washington University, St. Louis, MO, United States
Indiana University, Bloomington, IN, United States
Rush University, Chicago, IL, United States
Kaiser Permanente, Oakland, CA, United States
Coalition for Aligning Science, Washington, WA, United States
Banner Sun Health Research Institute, Sun City, AZ, United States
Michigan State University, East Lansing, MI, United States
Cleveland Clinic, Cleveland, OH, United States
Northwestern University, Evanston, IL, United States
Baylor College of Medicine, Houston, TX, United States
Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, United States
University of Miami Miller School of Medicine, Miami, FL, United States
Beth Israel Deaconess Medical Center, Boston, MA, United States
North Shore University Health System, Chicago, IL, United States
Institute for Neurodegenerative Disorders, New Haven, CT, United States
University of Pittsburgh, Pittsburgh, PA, United States
University of Alabama at Birmingham, Birmingham, AL, United States
University of Maryland, Baltimore, MD, United States
Northwestern University, Chicago, IL, United States
Universit of Michigan, Ann Arbor, MI, United States
Columbia University, New York, NY, United States
James J. Peters Veterans Affairs Medical Center, New York, NY, United States
Aligning Science Across Parkinson’s, Washington, WA, United States
University of Chicago, Chicago, IL, United States
Indiana University School of Medicine, Indianapolis, IN, United States
Sun Health Research Institution, Sun City, AZ, United States
Hue University, Huế, Viet Nam
University of Zambia, Lusaka, Zambia
Department of Clinical and Movement Neurosciences
University College London
Molecular Genetics Section
National Institutes of Health
Department of Clinical Research
The Michael J. Fox Foundation for Parkinson’s Research
Center for Alzheimer’s and Related Dementias (CARD)
Data Tecnica International
National Institute on Aging/National Institutes of Health
Department of Medical and Molecular Genetics
Integrative Genomics Unit
National Institute on Aging
Department of Neurology
Sanatorio de la Trinidad Mitre- INEBA
Hospital JM Ramos Mejia
Somnus Neurology Clinic
Neuroscience Research Australia
ANZAC Research Institute
Garvan Institute of Medical Research and Concord Repatriation General Hospital
Concord Hospital
QIMR Berghofer Medical Research Institute
Murdoch University
Medical University Vienna Austria
Universidade Federal do Rio Grande do Sul / Hospital de Clínicas de Porto Alegre
Federal University of Health Sciences of Porto Alegre
Universidade Federal do Rio Grande do Sul
University of São Paulo
Universidade Federal de Minas Gerais
Montreal Neurological Institute
Institut universitaire de gériatrie de Montréal
McGill University
Universidad de Chile
Fundación Diagnosis
Faculty of Medicine Universidad de Chile
CETRAM
Central South University
West China Hospital Sichuan University
Xiangya Hospital
Capital Medical University
Zhejiang University
Universidad Nacional de Colombia
Fundación Valle del Lili
University of Antioquia
University of Costa Rica
The American University in Cairo
Beni-Suef University
Addis Ababa University
Paris Brain Institute
Sorbonne Université
University of Lübeck
Deutsches Zentrum für Neurodegenerative Erkrankungen
University Medical Center Göttingen
Department of Neurology
University of Lübeck and University Medical Center Schleswig-Holstein
University of Tubingen
University of Mainz
The German Center for Neurodegenerative Diseases
University of Ghana Medical School
University of Thessaly
Aristotle University of Thessaloniki
Ionian University
Biomedical research Foundation of the Academy of Athens
Diagnostic and Therapeutic Centre HYGEIA Hospital
Hospital San Felipe
Queen Elizabeth Hospital
The Hong Kong University of Science and Technology
Aster Medcity
Sree Chitra Tirunal Institute for Medical Sciences and Technology
National Institute of Mental Health & Neurosciences
Manipal Hospital
All India Institute of Medical Sciences
Nizam’s Institute Of Medical Sciences
Shahid Beheshti University of Medical Science
Magna Græcia University of Catanzaro
University of Pavia
University of Perugia
University of Rome Tor Vergata
Juntendo University
Juntendo University faculty of medicine
Jikei University School of Medicine
Institute of Neurology and Neurorehabilitation
Kyrgyz State Medical Academy
University of Luxembourg
University of Malaya
Universiti Kebangsaan Malaysia
UKM Medical Molecular Biology Institute
Universiti Kebangsaan Malaysia Medical Centre
International Islamic University
Tecnologico de Monterrey
Instituto Nacional de Neurologia y Neurocirugia
Universidad Nacional Autónoma de México
Mongolian National University of Medical Sciences
Tribhuvan University
University of Otago
University of Lagos
College of Medicine of the University of Lagos
Norwegian University of Science and Technology
Oslo University Hospital
University of Science and Technology Bannu
Universidad Cientifica del Sur
Metropolitan Medical Center
University of Puerto Rico
Research Center of Neurology
King Faisal Specialist Hospital and Research Center
King Abdullah International Medical Research Center
National Neuroscience Institute
Nanyang Technological University
University of KwaZulu-Natal
University of Stellenbosch
Stellenbosch University
Seoul National University Hospital
Yongin Severance Hospital
Hospital Universitario Burgos
University Hospital Mutua Terrassa
Institut de Recerca Sant Joan de Deu
Research Institute Germans Trias i Pujol
Instituto de Biomedicina de Sevilla
University Hospital Germans Trias i Pujol
Faculty of medicine university of Khartoum
Inselspital Bern
National Taiwan University Hospital
Chang Gung Memorial Hospital
National Taiwan University
National Institute Mongi Ben Hamida of Neurology
Mongi Ben Hmida National Institute of Neurology
Koç University
Sisli Etfal Training and Research Hospital
Queen Mary University of London
University of Plymouth
Parkinson’s UK
University of Glasgow
Cardiff University
Royal Veterinary College University of London
University of Bristol
Cure Parkinson’s
University of Cincinnati
Augusta University / University of Georgia Medical Partnership
Mid-Atlantic Permanente Medical Group
Washington University
Indiana University
Rush University
Kaiser Permanente
Coalition for Aligning Science
Banner Sun Health Research Institute
Michigan State University
Cleveland Clinic
Northwestern University
Baylor College of Medicine
Baylor College of Medicine
University of Miami Miller School of Medicine
Beth Israel Deaconess Medical Center
North Shore University Health System
Institute for Neurodegenerative Disorders
University of Pittsburgh
University of Alabama at Birmingham
University of Maryland
Northwestern University
Universit of Michigan
Columbia University
James J. Peters Veterans Affairs Medical Center
Aligning Science Across Parkinson’s
University of Chicago
Indiana University School of Medicine
Sun Health Research Institution
Hue University
University of Zambia
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