Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development
Tominaga M. Uto T. Fukaya T. Mitoma S. Riethmacher D. Umekita K. Yamashita Y. Sato K.
2024Frontiers Media SA
Frontiers in Immunology
2024#15
Dendritic cells (DCs) are known as unique professional antigen (Ag)-presenting cells (APCs) to prime naïve T cells for the initiation of adaptive immunity. While DCs are believed to play a pivotal role in generating anti-tumor T-cell responses, the importance of DCs in the protection from the progression of tumors remains elusive. Here, we show how the constitutive deficiency of CD11chi DCs influences the progression of tumors with the use of binary transgenic mice with constitutive loss of CD11chi DCs. Constitutive loss of CD11chi DCs not only enhances the progression of tumors but also reduces the responses of Ag-specific T cells. Furthermore, the congenital deficiency of CD11chi DCs generates the immunosuppressive tumor microenvironment (TME) that correlates with the marked accumulation of myeloid-derived suppressor cells (MDSCs) and the prominent productions of immunosuppressive mediators. Thus, our findings suggest that CD11chi DCs are crucial for generating anti-tumor T-cell responses and immunogenic TME to suppress the development of tumors. Copyright
anti-tumor T-cell responses , dendritic cells , immunosuppressive mediators , myeloid-derived suppressor cells , tumor development , tumor microenvironment
Text of the article Перейти на текст статьи
Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE), Japan Agency for Medical Research and Development (AMED), Tokyo, Japan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Division of Respirology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Rheumatology, Japan
Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
Division of Immunology
Department of Oral and Maxillofacial Surgery
Project for Promotion of Cancer Research and Therapeutic Evolution (P-PROMOTE)
Department of Biomedical Sciences
Division of Respirology
Frontier Science Research Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026