Regenerative properties of recombinant human erythropoietin in the wound healing
Toleubayev M. Dmitriyeva M. Kozhakhmetov S. Igissinov N. Turebayev D. Omarbekov A. Adaibayev K. Shakenov A. Izimbergenov M.
2021Open Access Macedonian Journal of Medical Sciences
Open Access Macedonian Journal of Medical Sciences
2021#9Issue F113 - 117 pp.
BACKGROUND: Erythropoietin (EPO) is the main stimulator of erythropoiesis, but EPO also has non-hematopoietic effects. The recent data show the positive effects of EPO on tissue regeneration. AIM: This review aims to know highlights the pathophysiological mechanisms of EPO at different stages of tissue regeneration, and possible clinical applications in wound healing. METHODS: A review of the literature considering reviews, clinical studies, original papers, and articles from electronic data has been used. RESULTS: Analysis of animal studies and several clinical trials using EPO in context of wound healing revealed that EPO has a positive effect on all stages of regeneration process and may be a promising therapeutic strategy for the treatment of chronic wounds. CONCLUSION: An improved understanding of the functions and regulatory mechanisms of EPO in the context of wound healing may lead to new considerations of this growth hormone for its regular clinical application in patients.
Erythropoietin , Re-epithelization , Skin , Vascular endothelial growth factor , Wound healing
Text of the article Перейти на текст статьи
Department of Public Health, Medical University of Astana, Nur-Sultan, Kazakhstan
Department of Surgery, Multidisciplinary city Hospital No. 1, Nur-Sultan, Kazakhstan
Department of Public Health
Department of Surgery
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026