2024 Comprehensive Recommendations of the Qazaq College of Rheumatology for the Diagnosis and Management of Sjögrens Syndrome
Togizbayev G. Aubakirova B. Dilmanova D. Zaripova L. Tabenova A. Karina K. Makalkina L.
May 2025John Wiley and Sons Inc
International Journal of Rheumatic Diseases
2025#28Issue 5
Background: Sjögrens syndrome (SjS) is a chronic autoimmune disease characterized by exocrine gland dysfunction and systemic involvement. Although international guidelines exist, regional adaptations are necessary to address specific healthcare settings. In 2024, the Qazaq College of Rheumatology (QCR) developed comprehensive national recommendations for the diagnosis and management of SjS in Kazakhstan. Methods: A panel of national experts reviewed and synthesized international guidelines (EULAR, ACR, and BSR) alongside local clinical data to create tailored diagnostic and therapeutic algorithms. Special emphasis was placed on the management of severe systemic manifestations and accessibility of therapies within Kazakhstans healthcare system. Results: The QCR recommendations propose a structured diagnostic approach combining clinical features, serological markers, and minor salivary gland biopsy. Treatment strategies emphasize non-pharmacological measures, symptomatic therapies, and immunomodulatory agents for systemic disease. Rituximab is prioritized as the first-line biologic for refractory severe extraglandular manifestations. A national registry for SjS is proposed to monitor implementation and outcomes. Conclusion: These guidelines aim to standardize the diagnosis and management of Sjögrens syndrome across Kazakhstan, improve patient outcomes, and support further research initiatives.
clinical guidelines , diagnosis , Kazakhstan , Qazaq College of Rheumatology (QCR) , Sjögrens syndrome , systemic therapy , treatment
Text of the article Перейти на текст статьи
Republican Rheumatology Center, Scientific Research Institute of Cardiology and Internal Diseases; Department of Rheumatology, Chief Rheumatologist of the Ministry of Health of the Republic of Kazakhstan; Chairman of the Qazaq College of Rheumatology, Almaty, Kazakhstan
Chief Rheumatologist of Astana; Rheumatologist, Astana, Kazakhstan
Department of Rheumatology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Head of Scientific and Innovative Management Department, National Scientific Medical Center, Astana, Kazakhstan
Department of Internal Medicine, University Medical Center, Astana, Kazakhstan
Department of Internal Diseases With Courses in Gastroenterology and Endocrinology, Astana Medical University, Astana, Kazakhstan
Department of Clinical Pharmacology, Astana Medical University, Astana, Kazakhstan
Republican Rheumatology Center
Chief Rheumatologist of Astana; Rheumatologist
Department of Rheumatology
Head of Scientific and Innovative Management Department
Department of Internal Medicine
Department of Internal Diseases With Courses in Gastroenterology and Endocrinology
Department of Clinical Pharmacology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026