Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions
Tippairote T. Bjørklund G. Gasmi A. Semenova Y. Peana M. Chirumbolo S. Hangan T.
October 2022MDPI
Nutrients
2022#14Issue 20
Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with low circulating CoQ10 levels. However, previous studies of oral CoQ10 supplementation yielded inconsistent outcomes. In this article, we reviewed previous CoQ10 trials, either single or in combination with other nutrients, and stratified the study participants according to their metabolic statuses and medical conditions. The CoQ10 supplementation trials in elders reported many favorable outcomes. However, the single intervention was less promising when the host metabolic statuses were worsening with the likelihood of multiple nutrient insufficiencies, as in patients with an established diagnosis of metabolic or immune-related disorders. On the contrary, the mixed CoQ10 supplementation with other interacting nutrients created more promising impacts in hosts with compromised nutrient reserves. Furthermore, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage, such as neurodegenerative disorders or cancers. With the limited high-level evidence studies on each host metabolic category, we could only conclude that the considerations of whether to take supplementation varied by the individuals’ metabolic status and their nutrient reserves. Further studies are warranted.
bioenergetics , coenzyme Q10 , combined supplements , dietary supplements , mitochondria , ubiquinone
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Department of Nutritional and Environmental Medicine, HP Medical Center, Bangkok, 10540, Thailand
Council for Nutritional and Environmental Medicine, Toften 24, Mo i Rana, 8610, Norway
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, 69100, France
School of Medicine, Nazarbayev University, Astana, 020000, Kazakhstan
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, via Vienna 2, Sassari, 07100, Italy
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, 37134, Italy
CONEM Scientific Secretary, Strada Le Grazie 9, Verona, 37134, Italy
Faculty of Medicine, Ovidius University of Constanta, Constanta, 900470, Romania
Department of Nutritional and Environmental Medicine
Council for Nutritional and Environmental Medicine
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
School of Medicine
Department of Chemical
Department of Neurosciences
CONEM Scientific Secretary
Faculty of Medicine
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