Factors Influencing on Pain in Patients Undergoing Pipelle Endometrial Biopsy for Abnormal Uterine Bleeding: Why a Personalized Approach Should Be Applied?

Terzic M. Aimagambetova G. Ukybassova T. Bapayeva G. Kaiyrlykyzy A. Foster F. Linkov F.
March 2022 MDPI

Journal of Personalized Medicine
2022 #12 Issue 3

Objectives. Abnormal uterine bleeding (AUB) is a common complaint of women in different age groups, and endometrial biopsy is widely used to investigate the underlying causes. The aim of this observational study was to assess factors influencing pain in patients undergoing endometrial biopsy for AUB. Methods. Pain intensity before, during, and after Pipelle sampling was evaluated using the numerical rating scale (NRS), where “0” represents no pain at all, “10”—the worst pain ever possible. Pain rating was categorized as 1–6—mild to moderate, 7 and above as severe pain. Results. The study included 160 women who underwent Pipelle biopsy. The median age in the cohort was 42 (34–48) years, 18.1% of women were postmenopausal, 56.3% were either overweight or obese, 30% were nulliparous and 80% reported urban residency. The median pain score during the procedure was 2 (0–4). Pain scores of 5 (4–7) were reported with the junior gynecologist and 2 (0–4) in the senior gynecologist (p < 0.0001). Conclusion. The pain was found to have a strong association with the type of provider performing the endometrial sampling procedure. This fact suggests the need for a personalized approach and that psychological or informational interventions should be scheduled before the procedure to decrease pain and increase satisfaction.

Abnormal uterine bleeding , Endometrial biopsy , Pain , Pipelle

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Department of Medicine, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Women’s Health, CF “University Medical Center”, Turan Ave. 32, Nur-Sultan, 010000, Kazakhstan
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, 15213, PA, United States
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan, 010000, Kazakhstan
National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Kabanbay Batyr Street, 53, Nur-Sultan, 010000, Kazakhstan
Health Administration and Public Health Department, Rangos School of Health Sciences, Duquesne University, 600 Forbes Ave, Pittsburgh, 15282, PA, United States

Department of Medicine
Clinical Academic Department of Women’s Health
Department of Obstetrics
Department of Biomedical Sciences
National Laboratory Astana
Health Administration and Public Health Department

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