Synthesis of Water-Soluble Polyethylene Glycol Fumarates for Biomedical Applications
Tazhbayev Y.M. Kazhmuratova A.T. Zhaparova L.Z. Tuleuov U.B. Nassikhatuly Y. Mitricheva E.S. Kwiatkowski A.L. Shibaev A.V.
2024E.A. Buketov Karaganda University Publish house
Eurasian Journal of Chemistry
2024#29Issue 24 - 12 pp.
Polyethylene glycol fumarate (PEGF) with controlled structural composition has been obtained for further synthesis of double network cross-linked hydrogels for biomedical applications. The copolymer has been syn-thesized by polycondensation reaction of fumaric acid and polyethylene glycol (PEG-600). Molecular weight of PEGF has been determined by gel permeation chromatography to be approximately 6000 Da with gel per-meation chromatography. The polycondensation of fumaric acid and PEG-600 was studied throughout the reaction process. The structure of the reaction product has been evidenced using FTIR-and 1H NMR-spectroscopy. The quantitative ratios of the amount of –C=C– bonds and –COO groups to –C=O groups in the obtained PEGF have been estimated from IR-spectra for different synthesis time. The time-dependence of molar ratio of double bonds to methyl groups in PEGF has been obtained from corresponding 1H NMR-spectra. FTIR and 1H NMR-spectroscopy, both, demonstrate that after the end of reaction the unsaturated –C=C– double bonds remain in the structure of the macromonomer, that is essential for further preparation of cross-linked hydrogels. The addition of the tightly cross-linked network of polyvinyl alcohol leads to for-mation of highly tough biocompatible material for preparation of the artificial meniscus which can further be used as a solution in the treatment of diseases such as osteoarthritis.
1H NMR-spectroscopy , FTIR-spectroscopy , fumaric acid , hydrogels , macromonomer , polyester resin , polyethylene glycol , polyethylene glycol fumarate
Text of the article Перейти на текст статьи
Karaganda Buketov University, Universitetskaya street, 28, Karaganda, 100024, Kazakhstan
Department of Organic Chemistry and Polymers, Faculty of Chemistry, Karaganda Buketov University, Universitetskaya street, 28, Karaganda, 100024, Kazakhstan
Research Institute on Chemical Problems, Karaganda Buketov University, Universitetskaya street, 28, Karaganda, 100024, Kazakhstan
Physics Department, Lomonosov Moscow State University, GSP-1, Lenenskiye Gory, 1, 2, Moscow, 119991, Russian Federation
Karaganda Buketov University
Department of Organic Chemistry and Polymers
Research Institute on Chemical Problems
Physics Department
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026