Synthesis and characterization of isoniazid immobilized polylactide-co-glycolide nanoparticles
Изониазидпен иммобилизацияланған полилактид-со-гликолид нанобөлшектерін синтездеу және зерттеу
Синтез и характеристика наночастиц полилактид-со-гликолида, иммобилизованных изониазидом
Tazhbayev Ye.M. Galiyeva A.R. Zhumagaliyeva T.S. Burkeyev M.Zh. Kazhmuratova A.T. Zhakupbekova E.Zh. Zhaparova L.Zh. Bakibayev A.A.
2021E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2021#101Issue 161 - 70 pp.
This article considers some aspects of synthesis and characterization of polylactide-co-glycolide nanoparticles immobilized with the antituberculous drug isoniazid. The influence of some synthesis parameters of nanoparticles (the ratio of drug substance: polymer and surfactant concentration) on properties of the obtained nanosomal drug form of isoniazid has been studied. Optimal conditions for obtaining the nanoparticles with the best physicochemical parameters such as: particle size, polydispersity, conversion, etc. have been found. These nanoparticles can be used as drug carriers.The results revealed that a polymer: drug ratio of 1:1 and the use of 3 % Twin 80 are necessary to obtain stable emulsions of nanoparticles of polylactide-co-glycolide with satisfactory characteristics. Average size of the obtained particles was 196.4 nm, and the polydispersity value was 0.323. The aggregation stability of nanoparticles during 4 hours at temperatures of 4ºC and 20ºC has been evaluated. The morphology of the obtained nanoparticles has been studied. Analysis of nanoparticles was characterized by various instrumental methods including gas chromatography and thermogravimetry techniques. The resulting nanoparticles of polylactide-co-glycolide immobilized with isoniazid are stable in time and can prolong the action of the drug. In vitro release of isoniazid from polylactide-co-glycolide nanoparticles has been studied.
Antituberculousdrug , Immobilization , Isoniazid , Nanoparticles , Polylactide-co-glycolide , Polymers
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Karagandy University of the name of academician E.A., Buketov, Kazakhstan
Tomsk State University, Russian Federation
Karagandy University of the name of academician E.A.
Tomsk State University
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