Association of inflammatory mediators and molecular markers of iron metabolism in pregnancies with pregestational obesity during the development of anaemia: a narrative review
Tayzhanova D. Rustembekkyzy Z. Komlichenko E. Ponamaryova O. Zhanabayeva S.
September 2024EDRA S.p.A
Italian Journal of Gynaecology and Obstetrics
2024#36Issue 3272 - 280 pp.
Obesity and anaemia are major problems all over the world; pregnancies often suffer from these medical conditions. Obesity is associated with an increased risk of iron deficiency associated with the activation of inflammatory markers and their influence on iron regulatory pathways. All of the pregnant obese women have a mild inflammatory response, which later leads to increased hepcidin levels, thereby influencing iron metabolism. The purpose of this review was to summarize recent findings that have reported the measuring of markers of iron metabolism and inflammatory in pregestationally obese pregnancies in the development of anaemia. This review examines obesity-related activation of inflammatory mediators as a potential primary cause of iron deficiency (ID) or iron deficiency anaemia (IDA) in obese pregnant women. Despite numerous studies, the effect of maternal weight on the risk of developing ID/IDA during pregnancy remains un-clear. Markers of iron metabolism in the background of inflammation are being considered. Pre-pregnancy obesity is associated with an increased risk of developing ID/IDA during pregnancy and in the postpartum period for mother and child.
inflammation , iron deficiency , iron deficiency anaemia , obesity , Pregnancy
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Department of Internal Diseases, Medical University of Karaganda NC JSC, Karaganda, Kazakhstan
Department of Obstetrics, Gynecology and Perinatology, Medical University of Karaganda NC JSC, Karaganda, Kazakhstan
Almazov National Medical Research Centre, North-Western State Medical University named I.I. Mechnikov, Saint-Petersburg, Russian Federation
Department of Biological Chemistry, Medical University of Karaganda NC JSC, Karaganda, Kazakhstan
Department of Internal Diseases
Department of Obstetrics
Almazov National Medical Research Centre
Department of Biological Chemistry
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