Association of Lung Fibrotic Changes and Cardiological Dysfunction with Comorbidities in Long COVID-19 Cohort

Tauekelova A.T. Kalila Z. Bakhtiyar A. Sautbayeva Z. Len P. Sailybayeva A. Khamitov S. Kadroldinova N. Barteneva N.S. Bekbossynova M.S.
February 2023 MDPI

International Journal of Environmental Research and Public Health
2023 #20 Issue 3

Background. Long COVID-19 symptoms appeared in many COVID-19 survivors. However, the prevalence and symptoms associated with long COVID-19 and its comorbidities have not been established. Methods. In total, 312 patients with long COVID-19 from 21 primary care centers were included in the study. At the six-month follow-up, their lung function was assessed by computerized tomography (CT) and spirometry, whereas cardiac function was assessed by elec-trocardiogram (ECG), Holter ECG, echocardiography, 24 h blood pressure monitoring, and a six-minute walk test (6MWT). Results. Of the 312 persons investigated, significantly higher sys-tolic and diastolic blood pressure, left ventricular hypertrophy, and elevated NT-proBNP were revealed in participants with hypertension or type 2 diabetes. Left ventricular diastolic dysfunc-tion was more frequently present in patients with hypertension. The most common registered CT abnormalities were fibrotic changes (83, 36.6%) and mediastinal lymphadenopathy (23, 10.1%). Among the tested biochemical parameters, three associations were found in long COVID-19 patients with hypertension but not diabetes: increased hemoglobin, fibrinogen, and ferritin. Nine patients had persisting IgM antibodies to SARS-CoV-2. Conclusions. We demon-strated a strong association between signs of cardiac dysfunction and lung fibrotic changes with comorbidities in a cohort of long COVID-19 subjects.

cardiovascular sequalae , diabetes , hypertension , long COVID-19 , lung sequelae , persisting IgM against SARS-CoV-2 , post-COVID-19

Text of the article Перейти на текст статьи

National Research Center for Cardiac Surgery, Astana, 010000, Kazakhstan
School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
School of Medicine, Nazarbayev University, Astana, 020000, Kazakhstan

National Research Center for Cardiac Surgery
School of Sciences and Humanities
School of Medicine

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026