Polymer-Protected Gold Nanoparticles for Photothermal Treatment of Ehrlich Adenocarcinoma: In Vitro and In Vivo Studies
Tatykhanova G.S. Tuleyeva R.N. Nurakhmetova Z.A. Gizatullina N.N. Krasnoshtanov V.K. Kaldybekov D.B. Aseyev V.O. Khutoryanskiy V.V. Kudaibergenov S.E.
February 2025John Wiley and Sons Inc
Macromolecular Chemistry and Physics
2025#226Issue 4
Photothermal therapy (PTT) is recognized as an effective tool for the treatment of cancer and it has attracted considerable attention of scientists. In this work, gold nanospheres (AuNSs) and gold nanorods (AuNRs) stabilized using poly(N-vinylpyrrolidone) (PVP), pristine gellan gum (PGG), and poly(2-ethyl-2-oxazoline)-grafted gellan gum (GG-g-PEtOx) are synthesized and evaluated as PTT agents in Ehrlich cancer cells. The physicochemical characteristics of these AuNSs and AuNRs, including their surface plasmon resonance absorption spectra, size, zeta potential, and aspect ratio are studied using UV–vis-spectroscopy, dynamic light scattering, zeta potential, transmission electron microscopy, and optical microscopy techniques. The polymer-protected AuNSs exhibit light-to-heat conversion, raising the temperature from 37 to 43 °C when irradiated using a visible light source. In the case of AuNSs, considerable damage to Ehrlich cancer cells is observed following irradiation and 40 days of examination. However, with regard to AuNSs, the damage to Ehrlich cancer cells is slightly lower than observed in AuNRs. In vivo experiments demonstrate that laser irradiation of tumors in mice after injecting AuNSs leads to a statistically significant decrease in tumor size as compared to those not irradiated and the control samples.
Ehrlich cancer cells , gold nanoparticles , gold nanorods , gold nanospheres , photothermal therapy (PTT) , surface plasmon resonance (SPR)
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Institute of Polymer Materials and Technology, Almaty, 050019, Kazakhstan
Satbayev University, Almaty, 050013, Kazakhstan
Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Kazakh Research Institute of Oncology and Radiology, Almaty, 050022, Kazakhstan
Department of Chemistry, University of Helsinki, Helsinki, 00014, Finland
Reading School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6DX, United Kingdom
Institute of Polymer Materials and Technology
Satbayev University
Department of Chemistry and Chemical Technology
Kazakh Research Institute of Oncology and Radiology
Department of Chemistry
Reading School of Pharmacy
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