Efficacy and safety of the indirect anticoagulant warfarin in its dosage based on the results of pharmacogenetic testing
Eficacia y seguridad del anticoagulante indirecto warfarina en su dosificación según los resultados de las pruebas farmacogenéticas
Tatyana S. Vladimirovich V.V. Raisovna I.V. Minkairovna S.L. Tatyana S. Tatyana P. Nikolaevich K.A. Sergeevna S.E.
2021Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology
Archivos Venezolanos de Farmacologia y Terapeutica
2021#40Issue 4451 - 454 pp.
Thrombotic complications are one of the main causes of death and disability, causing enormous economic damage to the state. There is an increase in the number of patients at high risk of these complications. The main aim of the article is to investigate efficacy and safety of the indirect anticoagulant warfarin in its dosage based on the results of pharmacogenetic testing. To achieve that aim, the use of drugs (JIC) from the group of indirect oral anticoagulants (ACND) is the only and uncontested method of long-term outpatient prevention of thrombosis-their effectiveness has been proven in primary and secondary prevention of throm-boembolic complications in patients with atrial fibrillation and, above all, ischemic stroke. AKND therapy reduces the risk of all strokes by an average of 62%. The advantage of AKND therapy has been proven in terms of preventing primary and recurrent thromboembolism.
Anti-coagulant , Application , Cardiology , Indirect anticoagulant warfarin , Patient
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Saint Petersburg State University of Medical faculty, Universitetskaya nab.,7/9, St Petersburg, 199034, Russian Federation
Department of State Budgetary Health Institution of Moscow region ≪Moscow regional research clinical Institute named after M. F. Vladimirsky≪, Moscow 61.2 Shchepkin street, building 1, Moscow, 1291102, Russian Federation
Fgbou Vo Bsmu Ministry of Health of Russia, st. Zaki Validi, 47, Ufa, 450008, Russian Federation
FGBOU VO BSMU MINISTRY OF HEALTH OF RUSSIA, Ufa, st. Zaki Validi, 47, Bashkortostan, 450008, Russian Federation
Kazakhstans Medical University KSPH, 19 a, Utepov st., Almaty, Kazakhstan
Krasnogo Vosstania. str., 1., Irkutsk, 664003, Russian Federation
National Research Mordovia State University, d. 68, St. Bolshevistskaya, Saransk, 430005, Russian Federation
Saint Petersburg State University of Medical faculty
Department of State Budgetary Health Institution of Moscow region ≪Moscow regional research clinical Institute named after M. F. Vladimirsky≪
Fgbou Vo Bsmu Ministry of Health of Russia
FGBOU VO BSMU MINISTRY OF HEALTH OF RUSSIA
Kazakhstans Medical University KSPH
Krasnogo Vosstania. str.
National Research Mordovia State University
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