Multifunctional Nanocellulose Hydrogels Featuring Superior Injectability, Self-Healing, Adhesion, and Near-infrared Photothermal Antibacterial Activity
Tang L. Shi D. Shen Y. Qi H. Liu Z. Yang L. Chen Z. Toshtay K. Toktarbay Z. Algadi H. Huang Z.
2025Engineered Science Publisher
ES Materials and Manufacturing
2025#28
Multifunctional hydrogels with self-healing capability, tissue adhesion, and photothermal antibacterial activity, hold significant potential for applications in wound healing. In this work, an injectable adhesive self-healing multiple-dynamic-bond crosslinked nanocellulose hydrogel (Fe@polydopamine (PDA)/2,2,6,6-tetramethylpiperidine oxygen radical (TEMPO) oxidized nanocellulose fiber (TOCF)/poly(vinyl alcohol) PVA) hydrogel, called FPTP) was formed by a multiple-dynamic-bond crosslinked network of dynamic ester bonds, hydrogen bond, ionic bond, etc. Due to the high density of dynamic bonds, the FPTP hydrogel demonstrated a highly inefficient self-healing behavior, only restoring to its original uncut state after one minute of healing. Inspired by the adhesion mechanism of mussels, the multifunctional FPTP hydrogel exhibited exceptional adhesive properties. The adhesion strength with pig skin is up to 6.5 kPa. After introducing Fe@PDA nanoparticles (Fe@PDA NPs), the multifunctional FPTP hydrogel demonstrated exceptional photothermal antibacterial activity under near-infrared (NIR) irradiation (S. aureus 97.89 % and E. coli 93.40 %). Simultaneously, the multifunctional FPTP hydrogel had excellent biocompatibility (cell viability > 95%). As no toxic antibacterial agents were employed, the hydrogel did not contribute to drug resistance. Consequently, with the adhesive, rapid self-healing ability, and NIR photothermal antibacterial effects, FPTP hydrogel holds significant promises for clinical applications.
Adhesion , Multifunctional hydrogel , Photothermal antibacterial , Self-healing
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Key Laboratory of Bio-based Material Science & Technology, Material Science and Engineering College, Northeast Forestry University, Harbin, 150040, China
Department of Orthopedics, Fuyang Hospital of Anhui Medical University, Fuyang, 236000, China
Al-Farabi Kazakh National University, Al-Farabi Avenue 71, Almaty, 050040, Kazakhstan
Department of Chemistry, Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University, 13 Dostyk Ave., Almaty, 050010, Kazakhstan
Department of Electrical Engineering, Faculty of Engineering, Najran University, Najran, 11001, Saudi Arabia
Key Laboratory of Bio-based Material Science & Technology
Department of Orthopedics
Al-Farabi Kazakh National University
Department of Chemistry
Department of Electrical Engineering
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