Non-alkaloid cholinesterase inhibitory compounds from natural sources
Tamfu A.N. Kucukaydin S. Yeskaliyeva B. Ozturk M. Dinica R.M.
September 2021MDPI
Molecules
2021#26Issue 18
Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.
Alzheimer’s disease , Cholinesterase inhibitors , Coumarins , Phenolic compounds , Terpenoids
Text of the article Перейти на текст статьи
School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundere, 454, Cameroon
Department of Chemistry, Mugla Sitki Kocman University, Mugla, 48000, Turkey
Department of Medical Services and Techniques, Koycegiz Vocational School of Health Services, Mugla Sitki Kocman University, Mugla, 48800, Turkey
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, Dunarea de Jos University, 47 Domneasca Str, Galati, 800008, Romania
School of Chemical Engineering and Mineral Industries
Department of Chemistry
Department of Medical Services and Techniques
Faculty of Chemistry and Chemical Technology
Department of Chemistry
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026