Advanced Biomaterials in Tissue Engineering Based on Antibacterial and Antibiofilm Nanocomposites for Multidrug-Resistant Wound Pathogens
Talipova A.B. Buranych V. Savitskaya I.S. Abashidze I. Malchik F.I. Shokatayeva D.H. Sahul M. Rokosz K. Čaplovičová M. Pogrebnjak A.D.
10 March 2026American Chemical Society
ACS Omega
2026#11Issue 914806 - 14820 pp.
The treatment of chronic wounds is critically challenged by resilient biofilms formed by multidrug-resistant (MDR) pathogens, which are largely impervious to conventional antibiotics. This study addresses this challenge by engineering a multifunctional hydrogel dressing that synergistically integrates bacterial cellulose (BC), MXene nanosheets, and hydroxyapatite (HAp). Plays a critical dual role in the composite, significantly boosting bioactivity while also stabilizing the MXene to prevent oxidation and maintain its antibacterial properties. As a result, the BC/MXene/HAp composite achieved a near-total (98%) eradication of viable cells in mature biofilms of challenging MDR pathogens, including MRSA and FQRPA. Such activity is driven by a dual-mechanism that effectively disrupts both the initial attachment of bacteria and the structural scaffold of established biofilms. Complementing this efficacy, in vitro assays with NIH-3T3 fibroblasts confirm that the composite supports excellent cell adhesion, proliferation, and metabolic activity, highlighting its high biocompatibility. This work demonstrates a nonantibiotic strategy to combat biofilms through a synergistically designed biomaterial. Given its robust performance and multifunctionality, this platform is a promising candidate for the development of advanced therapeutic dressings in regenerative wound care.
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Department of Biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Institute of Electrical Engineering, Slovak Academy of Sciences Dúbravská cesta 9, Bratislava, 84104, Slovakia
Health Policy and Management Department, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Laboratory of Electrochemical Production Technologies, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Institute of Materials Science, Faculty of Materials Science and Technology, Slovak University of Technology, J. Bottu 25, Trnava, 917 24, Slovakia
Faculty of Electronics and Computer Science, Koszalin University of Technology, Śniadeckich 2, Koszalin, PL 75-453, Poland
Centre for Nanodiagnostics of Materials, Slovak University of Technology in Bratislava, 5 Vazovova Street, Bratislava, 812 43, Slovakia
Biomedical Research Centre, Sumy State University, 116 Kharkivska Street, Sumy, 40007, Ukraine
Department of Biotechnology
Institute of Electrical Engineering
Health Policy and Management Department
Laboratory of Electrochemical Production Technologies
Institute of Materials Science
Faculty of Electronics and Computer Science
Centre for Nanodiagnostics of Materials
Biomedical Research Centre
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