Modeling brain pathology to study nose-to-brain drug delivery
Talgatkyzy A. Khaibullin T. Syzdykbayev M. Kazymov M. Sharapiyeva A. Amrenova K. Dinara S. Toktabayeva B. Khamitova M. Apsalikov B. Ozhmukhametova E.
2024Comenius University in Bratislava
Bratislava Medical Journal
2024#125Issue 7435 - 440 pp.
OBJECTIVES: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissue METHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block- polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used. RESULTS: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45–55 minutes, which promotes better penetration of drugs into the brain tissue. CONCLUSION: The polymer’s gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28). Text in PDF www.elis.sk
cytidine diphosphocholine , intranasal solution , pluronic F127
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Medical University Semey, Semey, Kazakhstan
NCJSC “Astana Medical University”, Astana, Kazakhstan
City Multidisciplinary Hospital No. 2 of the Akimat of Astana, Kazakhstan
Medical University Semey
NCJSC “Astana Medical University”
City Multidisciplinary Hospital No. 2 of the Akimat of Astana
10 лет помогаем публиковать статьи Международный издатель
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