Multifactorial analysis of the effect of albumin, creatinine, and TIMP-2 levels in acute kidney injury in pregnant women in the third trimester: Clinical research
Talgatbek A.Zh. Maidanova Z.O. Zubkov D.V. Amirbekova Z.T. Omertayeva D.E. Mugazov M.M.
2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 1127 - 133 pp.
Relevance: Acute kidney injury (AKI) in pregnant women in the third trimester is a serious clinical problem associated with a high risk of adverse outcomes for both mother and fetus. The development of AKI during this period may be due to various factors, including hypovolemia, preeclampsia, septic conditions, and obstetric complications. Currently, the diagnosis of AKI in pregnant women remains a difficult task since traditional biomarkers such as creatinine may not be informative enough due to physiological changes in kidney function during pregnancy. In this regard, new markers like TIMP-2 are of particular interest, which, in combination with other indicators, including albumin and creatinine levels, can provide a more complete picture of the degree of damage to renal tissue and the prognosis of the disease. Thus, the present study has high clinical significance and is aimed at improving the diagnosis of AKI in pregnant women in the third trimester, which may contribute to improving perinatal and maternal outcomes. The study aimed to evaluate the prognostic significance of albumin, creatinine, and TIMP-2 levels in pregnant women in the third trimester with acute kidney injury and develop a multifactorial model to improve the accuracy of acute kidney injury diagnosis and prediction. Materials and Methods: A prospective study that included 32 pregnant women in the third trimester with confirmed AKI. The albumin, creatinine, and TIMP-2 levels were evaluated dynamically at different stages of gestation. A multifactorial regression analysis was performed, considering age, concomitant extragenital diseases, and obstetric and gynecological history. The accuracy of the model was estimated using ROC curves. Results: It was shown that increased creatinine and TIMP-2 significantly correlated with a more severe course of OP in pregnant women (p < 0.001), and low albumin levels were associated with unfavorable pregnancy outcomes (p = 0.04). ROC analysis gave AUC=0.85, indicating the developed models high accuracy in predicting complications in this category of patients. Conclusion: The integrated use of albumin, creatinine, and TIMP-2 significantly improves the accuracy of diagnosis and prediction of AKI outcomes in pregnant women in the third trimester. The developed multifactorial model can be recommended for implementation in the clinical practice of perinatal centers.
albumin , creatinine , kidney , pregnant , TIMP-2
Text of the article Перейти на текст статьи
Obstetrics, Gynecology, and Perinatology Department, Karaganda Medical University, Karaganda, Kazakhstan
Karaganda Medical University, Karaganda, Kazakhstan
Department of Emergency Care, Anesthesiology and Resuscitation, Karaganda Medical University, Karaganda, Kazakhstan
Obstetrics
Karaganda Medical University
Department of Emergency Care
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026