Methods of Analysis and Identification of Betulin and Its Derivatives
Takibayeva A.T. Zhumabayeva G.K. Bakibaev A.A. Demets O.V. Lyapunova M.V. Mamaeva E.A. Yerkassov R.S. Kassenov R.Z. Ibrayev M.K.
August 2023Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2023#28Issue 16
This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin.
betulin , bioavailability , chemical transformation , the solubility of pentacyclic triterpenoids
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Department of Chemistry and Chemical Technologies, NJSC Karaganda Technical University Named after Abylkas Saginov, Karaganda, 100027, Kazakhstan
Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, 010000, Kazakhstan
Chemical Faculty, National Research Tomsk State University, Tomsk, 634028, Russian Federation
Chemical Faculty, National Research Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
Department of Organic Chemistry and Polymers, Chemistry Faculty, NJSC Karaganda University Named after Y.A. Buketov, Karaganda, 100024, Kazakhstan
Department of Chemistry and Chemical Technologies
Faculty of Natural Sciences
Chemical Faculty
Chemical Faculty
Department of Organic Chemistry and Polymers
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