Opportunities to Modulate Tumor Ecosystem Toward Successful Glioblastoma Immunotherapy
Takahashi M. Mukhamejanova D. Jasewicz H. Acharya N. Moon J.J. Hara T.
June 2025John Wiley and Sons Inc
Cancer Science
2025#116Issue 61482 - 1499 pp.
Over the past decade, the failure of multiple clinical trials has confirmed the need for a systematic and comprehensive understanding of glioblastoma (GBM). Current immunotherapies aiming to harness the immune system to achieve anti-tumor effects remain largely ineffective, highlighting the complexities of the GBM microenvironment. However, our recent understanding of immune niches within the central nervous system provides both opportunities and challenges in translating these insights into successful immunotherapy implementation. We discuss these strategies, including targeting multiple antigens within the heterogeneous GBM microenvironment, identifying new druggable targets to abrogate immunosuppression, and understanding niche-specific immune cell functionality to modulate tumor-immune-stroma interactions.
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Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, United States
Biointerfaces Institute, University of Michigan, Ann Arbor, MI, United States
Department of Neurosurgery, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, United States
Department of Biology, Nazarbayev University, Astana, Kazakhstan
Pelotonia Institute for Immuno-Oncology, OSUCCC–James, The Ohio State University, Columbus, OH, United States
Department of Neurology, the Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States
Department of Pharmaceutical Sciences
Biointerfaces Institute
Department of Neurosurgery
Department of Biology
Pelotonia Institute for Immuno-Oncology
Department of Neurology
Department of Biomedical Engineering
Department of Chemical Engineering
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026