Association of obesity with hematological indicators of inflammation in pregnant women
Taizhanova D.J. Rustembekkyzy Z. Amirbekova Z.T. Komlichenko E.V. Ponamareva O.A. Zhanabaeva S.U. Telegenova B.M.
1 April 2024Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2024#2024Issue 160 - 66 pp.
Relevance: Obesity is the abnormal or excessive accumulation of fat that is harmful to health. Many studies have shown that obesity causes an inflammatory response, leading to anemia and other adverse pregnancy outcomes. In our study, we aimed to examine the association between hematological markers of inflammation and obesity during pregnancy. The study aimed to evaluate the relationship between hematological markers of inflammation and obesity in pregnant women with anemia. Materials and Methods: The studies were conducted in the perinatal center at the regional clinical hospital in Karaganda. The clinical study enrolled 92 pregnant women between 2021 and 2022. Clinical data of patients located in the electronic archive of a medical organization was retrospectively analyzed. All examined women were divided into 4 groups: group 1 (n=25) – practically healthy (pregnant women without obesity and anemia); Group 2 (n=22) – pregnant women with anemia without obesity); Group 3 (n=23) – obese pregnant women without anemia; Group 4 (n=22) – pregnant women with obesity and anemia. Results: A detailed comparative analysis of hematological markers of peripheral blood revealed statistically significant differences (p>0.05) between groups in hemoglobin, erythrocyte sedimentation rate (ESR), lymphocytes, band neutrophils and eosinophils. According to the Mann-Whitney test, the values of a few hematological parameters: red blood cells, platelets and hematocrit were equivalent in the 3 and 4 groups (obese pregnant women). In addition, the level of leukocytes, band neutrophils, lymphocytes and eosinophils in these groups was higher than 1 and 2 groups (women without obesity) (p<0.05). Conclusion: Hematological markers of inflammation (leukocytes, neutrophils, and lymphocytes) were higher in pregnant women with obesity than in groups of healthy pregnant women (without obesity and anemia) and with anemia. It may predict adverse obstetric and neonatal outcomes in pregnant women.
anemia , BMI , inflammation , markers of inflammation , obesity , pregnancy
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Internal Medicine Department, Karaganda Medical University, Karaganda, Kazakhstan
Obstetrics, Gynecology and Perinatology Department, Karaganda Medical University, Karaganda, Kazakhstan
Institute of Perinatology and Pediatrics, Institute of Perinatology and Pediatrics “V.A. Almazov National Medical Research Center,”, St. Petersburg, Russian Federation
Biomedicine Department, Karaganda Medical University, Karaganda, Kazakhstan
Family Medicine Department, Karaganda Medical University, Karaganda, Kazakhstan
Internal Medicine Department
Obstetrics
Institute of Perinatology and Pediatrics
Biomedicine Department
Family Medicine Department
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