Association of Gene Polymorphism at Atrial Fibrillation in the Kazakh Population: Case—Control Study
Taizhanova D. Bazarova N. Kalimbetova A. Bodaubay R. Zholdybayeva E. Abylkanov C.
January 2026Multidisciplinary Digital Publishing Institute (MDPI)
Genes
2026#17Issue 1
Background/Objectives. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and represents a major public health problem. Genetic factors contribute to AF susceptibility, including variants associated with atrial remodeling. Methods. This case–control study investigated the rs3903239 polymorphism of the PRRX1 gene in a Kazakh population. The main group included patients with AF (n = 75), the control group consisted of 2 subgroups: subgroup 1 (control group 1) included conditionally healthy patients (n = 73), subgroup 2 (control group 2) consisted of patients with arterial hypertension (AH) and coronary heart disease (CHD) without diagnosed AF at the time of inclusion in the study (n = 50). Genotype and allele frequencies were compared between patients with AF and two control groups. The frequency of the rs3903239 polymorphism genotypes of the PRRX1 gene in the main group and in the control groups was in the Hardy–Weinberg equilibrium. Results. The frequency of the rare G allele (AG + GG genotypes) was higher in patients with AF compared with conditionally healthy controls; however, this difference did not reach statistical significance (OR 1.357; 95% CI 0.845–2.178). Conclusions. The observed differences represent a non-significant trend and do not demonstrate a statistically confirmed association between the rs3903239 polymorphism of the PRRX1 gene and AF in the Kazakh population.
atrial fibrillation , case—control study , gene polymorphism , Kazakh population , PRRX1 gene , rs3903239
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Department of Internal Diseases, Karaganda Medical University, 40 Gogolya Street, Karaganda, 100000, Kazakhstan
Administration Department, Regional Clinical Hospital of the Karaganda Region Health Department, 41 Yerubayev Street, Karaganda, 100000, Kazakhstan
Heart Rhythm Research Institute, Astana Medical University, 49A Beibitshilik Street, Astana, 010000, Kazakhstan
National Scientific Shared Laboratory of Biotechnology, National Center for Biotechnology, 13/5, Kurgalzhynskoye Road, Astana, 010000, Kazakhstan
Cardiology Department, Regional Clinical Hospital of the Karaganda Region Health Department, 41 Yerubayev Street, Karaganda, 100000, Kazakhstan
Department of Internal Diseases
Administration Department
Heart Rhythm Research Institute
National Scientific Shared Laboratory of Biotechnology
Cardiology Department
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