ASSOCIATION BETWEEN INTERLEUKIN-6 AND THROMBOMODULIN LEVELS AND PATHOMORPHOLOGICAL CHANGES IN EARLY REPRODUCTIVE LOSESS
Taizhanova D.Zh. Zubkov D.V. Kamyshansky E.K. Komlichenko E.V. Magalov I.Sh. Sorokina M.A.
2024Bionika Media Ltd.
Akusherstvo i Ginekologiya (Russian Federation)
2024#2024Issue 1091 - 100 pp.
Objective: The objective of the study was assessment of relationship between the prognostic values of laboratory serum markers and histopathological changes in early pregnancy loss. Materials and methods: The study included 269 women of reproductive age seeking healthcare in hospital due to reproductive loss before 12 weeks of pregnancy. Histomorphological structural changes were evaluated followed by comparative analysis of these changes and laboratory parameters, such as fibrinogen, leukocytes, interleukin-6 (IL-6), platelets, thrombomodulin (TM), and plasminogen activator inhibitor 1 (PAI-1), which are most often used in predicting reproductive losses. Results: Our study found statistically significant difference between the group of inflammatory changes versus the group of hemorrhagic/ischemic changes. The interquartile ranges for IL-6 were 5730–8840 ng/ml and 3540– 6910 ng/ml, respectively, that can serve as a prerequisite for determination of reference values for prediction of inflammatory factors at the pre-gravid stage. Also, there was statistically significant difference in TM levels. The interquartile range of TM in the group of inflammatory changes was 5430–6510 ng/ml versus 7120–9030 ng/ ml in the group of hemorrhagic/ischemic changes, that indicated a significant correlation between laboratory markers and the results of histological analysis of hemorrhagic changes. There were no statistically significant differences between the other laboratory parameters. Conclusion: According to analysis of histopathological changes before 12 weeks of pregnancy and two or more adverse pregnancy outcomes in history in female population in Kazakhstan, the main causes of reproductive losses are inflammatory and hemorrhagic disorders. The study showed that IL-6 as a predisposing factor of the causes of reproductive losses and TM as the gold standard for identification of coagulation and hemorrhagic defects, that cause miscarriage, can be considered to be the most significant prognostic laboratory criteria.
histology , interleukin-6 , reproductive losees , thrombomodulin
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Department of Internal Diseases, Karaganda Medical University, Gogol str., 40, Karaganda, Kazakhstan
Department of Obstetrics, Gynecology and Perinatology, Karaganda Medical University, Gogol str., 40, Karaganda, Kazakhstan
Pathological and Anatomical Unit, Clinic of the Karaganda Medical University, Ardak str., 1-3, Karaganda, Kazakhstan
Institute of Perinatology and Pediatrics, V.A. Almazov National Medical Research Center, St. Petersburg, Russian Federation
Department of Obstetrics and Gynecology, Baku branch of I.M. Sechenov First Moscow State Medical University, Baku, Azerbaijan
Department of Informatics and Biostatistics, Karaganda Medical University, Gogol str., 40, Karaganda, Kazakhstan
Department of Internal Diseases
Department of Obstetrics
Pathological and Anatomical Unit
Institute of Perinatology and Pediatrics
Department of Obstetrics and Gynecology
Department of Informatics and Biostatistics
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