Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2
Tahmasebi S. Saeed B.Q. Temirgalieva E. Yumashev A.V. El-Esawi M.A. Navashenaq J.G. Valizadeh H. Sadeghi A. Aslani S. Yousefi M. Jadidi-Niaragh F. Adigozalou J. Ahmadi M. Roshangar L.
1 July 2021Elsevier Inc.
Life Sciences
2021#276
In Coronavirus disease 2019 (COVID-19), a decreased number of regulatory T (Treg) cells and their mediated factors lead to a hyperinflammatory state due to overactivation of the inflammatory cells and factors during the infection. In the current study, we evaluated the Nanocurcumin effects on the Treg cell population and corresponding factors in mild and severe COVID-19 patients. To investigate the Nanocurcumin effects, 80 COVID-19 patients (40 at the severe stage and 40 at the mild stage) were selected and classified into Nanocurcumin and placebo arms. In both the Nanocurcumin and placebo groups, the Treg cell frequency, the gene expression of Treg transcription factor forkhead box P3 (FoxP3), and cytokines (IL-10, IL-35, and TGF-β), as well as the serum levels of cytokines were measured before and after treatment. In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-β, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. The abovementioned factors were remarkably increased in the post-treatment with Nanocurcumin before pre-treatment conditions. By contrast, it has been observed no notable alteration in the placebo group. Our findings revealed the SinaCurcumin® effective function in a significant increase in the number of Treg cells and their mediated factors in the Nanocurcumin group than in the placebo group in both mild and severe patients. Hence, it would be an efficient therapeutic agent in rehabilitating COVID-19 infected patients.
COVID-19 , Cytokine , Nanocurcumin , Regulatory T cell , SARS-CoV2 , Transcription factor
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Department of Immunology, Healthy Faculty, Tehran University of Medical Sciences, Tehran, Iran
Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates
Department of Clinical Farmacology, National Medical University, Almaty, Kazakhstan
Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russian Federation
Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt
Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Endodontics, Dental School, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology
Department of Clinical Sciences
Department of Clinical Farmacology
Department of Prosthetic Dentistry
Botany Department
Noncommunicable Diseases Research Center
Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences
Department of Immunology
Stem Cell Research Center
Department of Immunology
Department of Endodontics
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