Urtica dioica -Derived Phytochemicals for Pharmacological and Therapeutic Applications
Taheri Y. Quispe C. Herrera-Bravo J. Sharifi-Rad J. Ezzat S.M. Merghany R.M. Shaheen S. Azmi L. Prakash Mishra A. Sener B. Kiliç M. Sen S. Acharya K. Nasiri A. Cruz-Martins N. Tsouh Fokou P.V. Ydyrys A. Bassygarayev Z. Daştan S.D. Alshehri M.M. Calina D. Cho W.C.
2022Hindawi Limited
Evidence-based Complementary and Alternative Medicine
2022#2022
Urtica dioica belongs to the Urticaceae family and is found in many countries around the world. This plant contains a broad range of phytochemicals, such as phenolic compounds, sterols, fatty acids, alkaloids, terpenoids, flavonoids, and lignans, that have been widely reported for their excellent pharmacological activities, including antiviral, antimicrobial, antihelmintic, anticancer, nephroprotective, hepatoprotective, cardioprotective, antiarthritis, antidiabetic, antiendometriosis, antioxidant, anti-inflammatory, and antiaging effects. In this regard, this review highlights fresh insight into the medicinal use, chemical composition, pharmacological properties, and safety profile of U. dioica to guide future works to thoroughly estimate their clinical value.
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Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de la Frontera, Temuco, 4811230, Chile
Facultad de Medicina, Universidad Del Azuay, Cuenca, Ecuador
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El Ainy Street, Cairo, 11562, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October, 12451, Egypt
Department of Pharmacognosy, National Research Centre, Giza, Egypt
Department of Plant Sciences, LCWU, Lahore, 54000, Pakistan
Hygia Institute of Pharmaceutical Education and Research, U. P., Lucknow, 226001, India
Department of Pharmacology, University of Free State, Free State, Bloemfontein, 9300, South Africa
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Ankara, 06330, Turkey
Department of Pharmacognosy, Lokman Hekim University, Faculty of Pharmacy, Ankara, 06510, Turkey
Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, 700019, India
Department of Botany, Fakir Chand College, West Bengal, Diamond Harbour, 743331, India
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Faculty of Medicine, University of Porto, Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, PRD, Gandra, 4585-116, Portugal
TOXRUN-oxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, Gandra, 4585-116, Portugal
Department of Biochemistry, Faculty of Science, University of Bamenda, P.O. Box. 39, Bambili, Cameroon
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050040, Kazakhstan
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi av. 71, Almaty, 050040, Kazakhstan
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Phytochemistry Research Center
Facultad de Ciencias de la Salud
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Facultad de Medicina
Department of Pharmacognosy
Department of Pharmacognosy
Department of Pharmacognosy
Department of Plant Sciences
Hygia Institute of Pharmaceutical Education and Research
Department of Pharmacology
Gazi University
Department of Pharmacognosy
Molecular and Applied Mycology and Plant Pathology Laboratory
Department of Botany
Department of Pharmacology and Toxicology
Faculty of Medicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU)
TOXRUN-oxicology Research Unit
Department of Biochemistry
Biomedical Research Centre
Department of Biophysics
Department of Biology
Beekeeping Development Application and Research Center
Pharmaceutical Care Department
Department of Clinical Pharmacy
Department of Clinical Oncology
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