Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma
Tabynov K. Tailakova E. Rakhmatullayeva G. Bolatbekov T. Lim Y.H. Fomin G. Babayeva M. Valenta R. Tabynov K.
December 2025Nature Research
npj Vaccines
2025#10Issue 1
Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingual (SLIT) ASIT with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma. BALB/c mice were sensitized with Artemisia vulgaris pollen extract and treated with either rArt v 1-based SCIT adjuvanted with Montanide ISA-51, rArt v 1-based SLIT, an extract-based commercial SLIT vaccine, or PBS. Both rArt v 1-based SCIT and SLIT improved lung pathology and reduced airway reactivity following allergen challenge, with rArt v 1-based SCIT inducing Th1-polarized immune responses marked by increased IFN-γ production and rArt v 1-specific IgG1/IgG2a, while SLIT induced stronger mucosal IgA responses. These findings highlight the therapeutic potential of rArt v 1-based ASIT for mugwort allergy.
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International Center for Vaccinology, Kazakh National Agrarian Research University (KazNARU), Almaty, Kazakhstan
Preclinical Research Laboratory with Vivarium, M. Aikimbayev National Scientific Center for Especially Dangerous Infections, Almaty, Kazakhstan
T & TvaX LLC, Almaty, Kazakhstan
Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
University Malaysia Pahang al-Sultan Abdullah (UMPSA), Kuantan, Malaysia
Department of Pathophysiology and Allergy Research, Division of Immunopathology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
Laboratory for Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russian Federation
Center for Molecular Allergology, Karl Landsteiner University of Health Sciences, Krems, Austria
Life Improvement by Future Technologies (LIFT) Center, Moscow, Russian Federation
Republican Allergy Center, Research Institute of Cardiology and Internal Medicine, Almaty, Kazakhstan
International Center for Vaccinology
Preclinical Research Laboratory with Vivarium
T & TvaX LLC
Faculty of Biology and Biotechnology
University Malaysia Pahang al-Sultan Abdullah (UMPSA)
Department of Pathophysiology and Allergy Research
Laboratory for Immunopathology
Center for Molecular Allergology
Life Improvement by Future Technologies (LIFT) Center
Republican Allergy Center
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