SUCCESSFUL USE OF PROLONGED INHALATIONAL SURFACTANT THERAPY IN AN EXTREMELY SEVERE PATIENT WITH COVID-19-ASSOCIATED ACUTE RESPIRATORY DISTRESS SYNDROME
Syzdykbayev M. Tuleuov B. Kazymov M. Rustemova K. Alimkhanova G. Zheksenova A. Kazangapov R. Khamzina S. Abdikazimova S. Ismatov A. Khalelov S. Khripunov R.
1 November 2025
Georgian medical news
2025Issue 368146 - 150 pp.
Acute respiratory distress syndrome (ARDS) is a severe complication of COVID-19. During the pathogenesis of ARDS, a deficiency of alveolar surfactant could lead to severe hypoxemia. This report demonstrates that exogenous surfactant administration improves the overall clinical condition, reduces severe hypoxemia, and enhances the P/F ratio, thereby preventing the multiple organ dysfunction syndrome (MODS) that usually follows hypoxemia. In our experience, inhalational administration of surfactant preparations for one week was the key to successful treatment and recovery of extremely severe patients who would otherwise have had an unfavorable prognosis.
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Department of Anesthesiology and Reanimatology, Kazakhstan
2Emergency Hospital, Department of Surgery, Semey, Kazakhstan
Department of General Medical Practice, Kazakhstan
4Kokshetau State University named after Sh. Ualikhanov, State Scientific Research Institute of Life and Health Science, Department of Surgical Disciplines, Kazakhstan
5NJSC Scientific Center of Pediatrics and Pediatric Surgery, Department of Anesthesiology, Almaty, Kazakhstan
Department of Surgery, Astana, Kazakhstan
7Pavlodar Branch of Semey Medical University, Kazakhstan
8Kokshetau State University named after Sh. Ualikhanov, Higher School of Medicine, Department of Clinical Disciplines, Kazakhstan
9Hospital City, Department of Surgery, Astana, Kazakhstan
Department Maxillofacial Surgery, Kazakhstan
Department Anesthesiology and Reanimatology, Ust-Kamenogorsk, 11East Kazakhstan Regional Specialized Medical Center, Kazakhstan
Department of Anesthesiology and Reanimatology
2Emergency Hospital
Department of General Medical Practice
4Kokshetau State University named after Sh. Ualikhanov
5NJSC Scientific Center of Pediatrics and Pediatric Surgery
Department of Surgery
7Pavlodar Branch of Semey Medical University
8Kokshetau State University named after Sh. Ualikhanov
9Hospital City
Department Maxillofacial Surgery
Department Anesthesiology and Reanimatology
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