Spectral characteristics and interrogation of a fiber-optic ball resonator biosensor modulated by a tilted fiber Bragg grating

Sypabekova M. Amantayeva A. Gonzalez-Vila A. Shaimerdenova M. Caucheteur C. Tosi D.
September 2023 Academic Press Inc.

Optical Fiber Technology
2023 #79

In this work, we describe the design and analyze the characteristic of a fiber-optic biosensing device formed by a fiber-tip ball resonator (BR) assisted by an in-line tilted fiber Bragg grating (TFBG). The BR-TFBG device acts as miniature fiber-tip biosensor, characterized by a broad reflection spectrum remodulated by the cladding modes of the grating that enhance the amplitude sensitivity. We demonstrate an interrogation method that improves the sensitivity on the cladding mode comb, showing a sensitivity up to 274.0 dB/RIU in amplitude by using polarization-based analysis, and 154.7 nm/RIU for wavelength shift by using a cross-correlation method. Then, we demonstrate the biosensing application of the BR-TFBG for the detection of human epidermal growth factor receptor-2 (HER2) in buffer, within 0.5 – 128.0 ng/ml concentration.

Ball resonator , Cancer biomarker detection , Fiber optic biosensors , HER2 (human epidermal growth factor receptor 2) , Optical biosensors , Tilted fiber Bragg grating (TFBG)

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School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana, 010000, Kazakhstan
Department of Electrical & Computer Engineering, Baylor University, Waco, TX, United States
Electromagnetism and Telecommunication Department, University of Mons, Mons, 7000, Belgium
Laboratory of Biosensors and Bioinstruments, National Laboratory Astana, 53, Kabanbay Batyr, Astana, 010000, Kazakhstan

School of Engineering and Digital Sciences
Department of Electrical & Computer Engineering
Electromagnetism and Telecommunication Department
Laboratory of Biosensors and Bioinstruments

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