Genetic Predisposition to Prediabetes in the Kazakh Population
Svyatova G. Berezina G. Murtazaliyeva A. Dyussupov A. Belyayeva T. Faizova R. Dyussupova A.
October 2024Multidisciplinary Digital Publishing Institute (MDPI)
Current Issues in Molecular Biology
2024#46Issue 1010913 - 10922 pp.
The aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data associated with the risk of developing prediabetes, in an ethnically homogeneous Kazakh population compared to previously studied populations worldwide. This study utilized a genomic database consisting of 1800 ethnically Kazakh individuals who were considered in healthy condition. Whole-genome genotyping was performed using Illumina OmniChip 2.5–8 arrays, which interrogated approximately 2.5 million single nucleotide polymorphisms. The distribution of genotypes for the TCF7L2 (rs7903146) and PPARG (rs1801282) polymorphisms in the Kazakh sample was found to be in Hardy–Weinberg equilibrium (p > 0.05). The minor G allele of the “Asian” protective polymorphism rs1801282 in the PPARG gene was observed at a frequency of 13.8% in the Kazakh population. This suggests a potentially more significant protective effect of this polymorphism in reducing the risk of prediabetes among Kazakhs. The frequency of the unfavorable T allele of the insulin secretion-disrupting gene TCF7L2 (rs7903146) in Kazakhs was 15.2%. Studying the associations of genetic markers for prediabetes enables the timely identification of “high-risk groups” and facilitates the implementation of effective preventive measures. Further results from replicative genomic research will help identify significant polymorphic variants of genes underlying the alteration of prediabetes status.
gene polymorphisms , GWAS analysis , minor alleles , prediabetes
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Laboratory of Republican Medical Genetic Consultation, Scientific Center of Obstetrics, Gynecology, and Perinatology, Almaty, 050020, Kazakhstan
Department of General Medical Practice, Semey Medical University, Semey, 071400, Kazakhstan
Laboratory of Republican Medical Genetic Consultation
Department of General Medical Practice
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