Bartter syndrome in neonatology practice: clinical and laboratory characteristics and management (A clinical case)
Неонатология тәжірибесіндегі Барттер синдромы: клиникалық-зертханалық сипаттамасы және жүргізу ерекшеліктері (клиникалық жағдай)
Синдром Барттера в практике неонатолога: клинико-лабораторная характеристика и особенности ведения (клинический случай)
Suleimenova I.E. Bozhbanbayeva N.S. Sairankyzy S. Maykupova R.A. Duisebay G.N. Orazali U.N.
30 December 2025Kaz Med Print LLP
Reproductive Medicine (Central Asia)
2025#2025Issue 4257 - 268 pp.
Relevance: Neonatal Bartter syndrome is an extremely rare genetic disorder that causes serious metabolic disorders in newborns and requires careful study to develop effective diagnostic and treatment methods. The study aimed to examine in depth the pathogenesis, clinical manifestations, and genetic aspects of neonatal Bartter syndrome, and to develop recommendations for more effective diagnosis, treatment, and monitoring of patients with this disease. Materials and Methods: A systematic review and analysis of literature sources published by clinicians, researchers, and professional associations in the fields of perinatology, neonatology, nephrology, and pediatrics was conducted. We searched the PubMed, Google Scholar, Scirus, Medline, Wiley, and Cochrane Library databases over the past 15 years using research keywords. The following is a clinical case of a newborn with neonatal Bartter syndrome who was in the Department of Highly Dependent Newborns at the Center for Perinatology and Pediatric Cardiac Surgery (Almaty, Kazakhstan). The course of pregnancy, the mother’s anamnesis, and data from clinical, laboratory, and instrumental studies were studied. Results: The analysis of literary sources led to the development of tables of clinical and pathophysiological classification, diagnostic algorithms, and approaches to the treatment and monitoring of patients with Bartter syndrome. Conclusion: To diagnose this syndrome, attention should be paid to premature newborns who have polyhydramnios, growth retardation, or electrolyte imbalance (Na, K, Ca, Cl). The data presented in this review and the tables of the clinical and pathophysiological classification of SB developed by us, the diagnostic algorithms, and approaches to treatment and monitoring of patients with Bartter syndrome can be useful for doctors, which contributes to improving the diagnosis and treatment of this disease in the medical practice of neonatologists. Â
Bartter syndrome , electrolyte imbalance , hypokalemia , intrauterine growth retardation , metabolic alkalosis , newborn , tubulopathy
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Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University
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