Predictive value of 18F-fluorodeoxyglucose accumulation in visceral fat activity to detect colorectal cancer metastases (prospective observational cohort study)
Suleimanov A. Saduakassova A. Vinnikov D. Pokrovsky V. Mamyrbekova S. Daniyarova A. Kozhabek L.
2022F1000 Research Ltd
F1000Research
2022#11
Background: To evaluate functional visceral adipose tissue (VAT) activity assessed by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) as a predictive factor of metastases in colorectal cancer (CRC) patients. Methods: We reviewed study protocols and PET/CT data of 534 CRC patients; 474 patients were subsequently excluded for various reasons. The remaining 60 patients with histologically confirmed adenocarcinoma were then prospectively assessed and were exposed to 18F-FDG PET/CT after a surgical treatment and chemoradiotherapy. Age, histology, stage, and tumor grade data were recorded. Functional VAT activity was verified with maximum standardized uptake value (SUV max) using 18F-FDG PET/CT and tested as a predictive factor of later metastases in eight subdomains of abdominal regions (RE – epigastric region, RLH – left hypochondriac region, RRL – right lumbar region, RU – umbilical region, RLL – left lumbar region, RRI – right inguinal region, RP – hypogastric (pubic) region, RLI – left inguinal region) and pelvic cavity (P) in the adjusted regression models. In addition, we studied the best areas under the curve (AUC) for SUV max with the corresponding sensitivity (Se) and specificity (Sp). Results: In both adjusted for age regression models and receiver operating characteristic (ROC) curve analysis, 18F-FDG accumulation in RLH (cut-off SUV max 0.74; Se 75%; Sp 61%; AUC 0.668; p=0.049), RU (cut-off SUV max 0.78; Se 69%; Sp 61%; AUC 0.679; p=0.035), RRL (cut-off SUV max 1.05; Se 69%; Sp 77%; AUC 0.682; p=0.032) and RRI (cut-off SUV max 0.85; Se 63%; Sp 61%; AUC 0.672; p=0.043) could predict later metastases in CRC patients, as opposed to age, sex, primary tumor location, tumor grade and histology. Conclusions: Functional VAT activity was importantly related to later metastases in CRC patients and can be used as their predictive factor. Copyright:
18F-FDG , Colorectal cancer , PET/CT , Predictive value
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Faculty of Medicine and Health Care, Al-Farabi Kazakh National University, Almaty, Almaty, 050040, Kazakhstan
Nuclear Medicine Department of the Diagnostic Center, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Nur-Sultan, Nur-Sultan, 010000, Kazakhstan
Department of biochemistry, Peoples’ Friendship University of Russia (RUDN University), Moscow, Moscow, 117198, Russian Federation
Laboratory of combined therapy of tumors, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Moscow, 115478, Russian Federation
Faculty of Medicine and Health Care
Nuclear Medicine Department of the Diagnostic Center
Department of biochemistry
Laboratory of combined therapy of tumors
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