Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles
Stepanenko V. Kaprin A. Ivanov S. Shegay P. Bogacheva V. Sato H. Shichijo K. Toyoda S. Kawano N. Ohtaki M. Fujimoto N. Endo S. Chaizhunusova N. Shabdarbaeva D. Zhumadilov K. Hoshi M.
1 September 2022Oxford University Press
Journal of Radiation Research
2022#63I21 - I25 pp.
Manganese-56 (56Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of 56Mn and the radiation emission from excited levels of 56Fe following 56Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated 56Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to 56Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around 56Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated 56Mn dioxide powder.
56Mn radioactive microparticles , A-bombing , alveoli , internal irradiation , lungs , radiation dose microdistribution
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A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Radiological, Center of the Ministry of Health of the Russian Federation, Koroleva Str., 4., Kaluga Region, Obninsk, 2490036, Russian Federation
National Medical Research Radiological, Center of the Ministry of Health of the Russian Federation, Koroleva Str., 4., Kaluga Region, Obninsk, 2490036, Russian Federation
Ibaraki Prefectural University of Health Sciences, 4669-2, Ami-chyo Ami, Inashiki-gun, Ibaraki, 300-0394, Japan
Atomic Bomb Disease Institute, Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan
Department of Applied Physics, Okayama University of Science, 1-1 Ridai, Kita-ku, Okayama, 700-0005, Japan
The Center for Peace Hiroshima University, Higashisenda-machi 1-1-89, Naka-ku, Hiroshima, 730-0053, Japan
Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1, Kagamiyama, Higashi, Hiroshima, 739-8527, Japan
Semey State Medical University, Abay Str., 103, Semey, 071400, Kazakhstan
Eurasian National University named after L.N. Gumilyov, Munaipasova Str. 13, Astana, 010008, Kazakhstan
A. Tsyb Medical Radiological Research Center
National Medical Research Radiological
Ibaraki Prefectural University of Health Sciences
Atomic Bomb Disease Institute
Department of Applied Physics
The Center for Peace Hiroshima University
Research Institute for Radiation Biology and Medicine
Graduate School of Advanced Science and Engineering
Semey State Medical University
Eurasian National University named after L.N. Gumilyov
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