Internal radiation dose estimates in organs of Wistar rats exposed to sprayed neutron-activated 31SiO2 microparticles: first results of international multicenter study
Stepanenko V. Sato H. Kaprin A. Fujimoto N. Kushugulova A. Ivanov S. Shegay P. Bogacheva V. Petukhov A. Zhumadilov K. Ostroumova E. Yasuda H. Kawano N. Ohtaki M. Endo S. Sakaguchi A. Chulenbayeva L. Mukhanbetzhanov N. Hoshi M.
November 2024Oxford University Press
Journal of Radiation Research
2024#65Issue 6744 - 751 pp.
Neutron-activated 31Si is an almost pure beta emitter and is one of the short-lived radionuclides, including beta-gamma emitter 56Mn, which were created in a form of residual radioactivity in the early period after the atomic bombing of Hiroshima and Nagasaki. The features of the biological effects of internal irradiation by these radionuclides are a subject of scientific discussions and research. The publication presents data on internal radiation doses in experimental Wistar rats that were exposed to sprayed neutron-activated microparticles of 31SiO2. Doses of internal radiation could be conditionally divided into three groups according to their values. It has been found that elevated values of internal radiation doses in rats’ organs/tissues as a result of exposure to sprayed 31SiO2 microparticles with initial activity of 3.2 × 107 Bq varied from 10 to 120 mGy (eyes, lungs, skin, stomach, jejunum, large intestine). The moderate dose values were in the range from 1.9 to 3.7 mGy (trachea, esophagus, ileum). The smallest doses were received by the kidney, testis, blood, cerebellum, heart, liver, cerebrum, bladder, spleen and thymus (from 0.11 to 0.94 mGy). The obtained data are important for interpreting the results of ongoing and planned biological experiments with 31SiO2 microparticles—in comparison with the previously published data on features of biological effects caused by beta-gamma emitting 56MnO2 neutron-activated microparticles.
31SiO2 , atomic bombing , dosimetry , internal irradiation , neutron activation , radioactive microparticles , Wistar rats
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A. Tsyb Medical Radiological Research Center, Branch of the National Medical Research, Radiological Centre of the Ministry of Health of the Russian Federation, 4 Koroleva St., Kaluga Region, Obninsk, 249036, Russian Federation
Ibaraki Prefectural University of Health Sciences, 4669-2 Ami, Ami-machi, Ibaraki, Inashiki-gun, 300-0394, Japan
National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, 4 Koroleva St., Kaluga Region, Obninsk, 249036, Russian Federation
Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
P.A. Hertzen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, 2nd Botkinsky Drive 3, Moscow, 125284, Russian Federation
Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Nazarbayev University, 53 Kabanbay Batyr Avenue, Astana City, 010000, Kazakhstan
International Department of Nuclear Physics, New Materials and Technology, L. N. Gumilyov Eurasian National University, 13 Munaitpasova St., Astana City, 010008, Kazakhstan
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer/WHO, 25 Avenue Tony Garnier, Lyon, 69366, France
The Center for Peace, Hiroshima University, Higashisenda-machi 1-1-89, Naka-ku, Hiroshima, 730-0053, Japan
Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1, Kagamiyama, Higashi, Hiroshima, 739-8527, Japan
Institute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba, 305-8577, Japan
A. Tsyb Medical Radiological Research Center
Ibaraki Prefectural University of Health Sciences
National Medical Research Radiological Centre
Peoples’ Friendship University of Russia
P.A. Hertzen Moscow Oncology Research Institute
Research Institute for Radiation Biology and Medicine
Nazarbayev University
International Department of Nuclear Physics
Environment and Lifestyle Epidemiology Branch
The Center for Peace
Graduate School of Advanced Science and Engineering
Institute of Pure and Applied Sciences
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