Synthesis of 4,5-dihydro-1H-pyrazole derivatives based on 3-acetyl-5-nitropyridines

Stalinskaya A.L. Weber D.F. Seilkhanov T.M. Kulakov I.V.
March 2021 Springer

Monatshefte fur Chemie
2021 #152 Issue 3 337 - 343 pp.

Claisen–Schmidt-type aldol-crotonic condensation of 3-acetyl-5-nitropyridine derivatives with various aromatic aldehydes was used for the preparation of pyridylchalcones. Cyclization of the latter with hydrazine hydrate in acetic acid afforded the corresponding N-acetyl derivatives of 4,5-dihydro-1H-pyrazole. Graphic abstract: [Figure not available: see fulltext.]

4,5-Dihydro-1H-pyrazoles , 5-Nitropyridines , Pyridylchalcones

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Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., Tyumen, 625003, Russian Federation
Sh. Ualikhanov Kokshetau State University, 76 Abaya St, Kokshetau, 020000, Kazakhstan

Institute of Chemistry
Sh. Ualikhanov Kokshetau State University

10 лет помогаем публиковать статьи Международный издатель

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