Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives
Stalinskaya A.L. Martynenko N.V. Shulgau Z.T. Shustov A.V. Keyer V.V. Kulakov I.V.
June-2 2022MDPI
Molecules
2022#27Issue 12
The COVID-19 pandemic is ongoing as of mid-2022 and requires the development of new therapeutic drugs, because the existing clinically approved drugs are limited. In this work, seven derivatives of epoxybenzooxocinopyridine were synthesized and tested for the ability to inhibit the replication of the SARS-CoV-2 virus in cell cultures. Among the described compounds, six were not able to suppress the SARS-CoV-2 virus’ replication. One compound, which is a derivative of epoxybenzooxocinopyridine with an attached side group of 3,4-dihydroquinoxalin-2-one, demonstrated antiviral activity comparable to that of one pharmaceutical drug. The described compound is a prospective lead substance, because the half-maximal effective concentration is 2.23 µg/µL, which is within a pharmacologically achievable range.
antiviral activity , epoxybenzooxocinopyridine derivatives , SARS-CoV-2
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Institute of Chemistry, Tyumen State University, 15a Perekopskaya St., Tyumen, 625003, Russian Federation
National Center for Biotechnology, 13/5 Kurgalzhynskoe road, Nur-Sultan, 010000, Kazakhstan
Institute of Chemistry
National Center for Biotechnology
10 лет помогаем публиковать статьи Международный издатель
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