Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents
Solmi M. Thompson T. Cortese S. Estradé A. Agorastos A. Radua J. Dragioti E. Vancampfort D. Thygesen L.C. Aschauer H. Schlögelhofer M. Aschauer E. Schneeberger A.A. Huber C.G. Hasler G. Conus P. Do Cuénod K.Q. von Känel R. Arrondo G. Fusar-Poli P. Gorwood P. Llorca P.-M. Krebs M.-O. Scanferla E. Kishimoto T. Rabbani G. Skonieczna-Żydecka K. Brambilla P. Favaro A. Takamiya A. Zoccante L. Colizzi M. Bourgin J. Kamiński K. Moghadasin M. Seedat S. Matthews E. Wells J. Vassilopoulou E. Gadelha A. Su K.-P. Kwon J.S. Kim M. Lee T.Y. Papsuev O. Manková D. Boscutti A. Gerunda C. Saccon D. Righi E. Monaco F. Croatto G. Cereda G. Demurtas J. Brondino N. Veronese N. Enrico P. Politi P. Ciappolino V. Pfennig A. Bechdolf A. Meyer-Lindenberg A. Kahl K.G. Domschke K. Bauer M. Koutsouleris N. Winter S. Borgwardt S. Bitter I. Balazs J. Czobor P. Unoka Z. Mavridis D. Tsamakis K. Bozikas V.P. Tunvirachaisakul C. Maes M. Rungnirundorn T. Supasitthumrong T. Haque A. Brunoni A.R. Costardi C.G. Schuch F.B. Polanczyk G. Luiz J.M. Fonseca L. Aparicio L.V. Valvassori S.S. Nordentoft M. Vendsborg P. Hoffmann S.H. Sehli J. Sartorius N. Heuss S. Guinart D. Hamilton J. Kane J. Rubio J. Sand M. Koyanagi A. Solanes A. Andreu-Bernabeu A. San José Cáceres A. Arango C. Díaz-Caneja C.M. Hidalgo-Mazzei D. Vieta E. Gonzalez-Peñas J. Fortea L. Parellada M. Fullana M.A. Verdolini N. Andrlíková E. Janků K. Millan M.J. Honciuc M. Moniuszko-Malinowska A. Łoniewski I. Samochowiec J. Kiszkiel Marlicz M. Sowa P. Marlicz W. Spies G. Stubbs B. Firth J. Sullivan S. Darcin A.E. Aksu H. Dilbaz N. Noyan O. Kitazawa M. Kurokawa S. Tazawa Y. Anselmi A. Cracco C. Machado A.I. Estrade N. De Leo D. Curtis J. Berk M. Carvalho A.F. Ward P. Teasdale S. Rosenbaum S. Marx W. Horodnic A.V. Oprea L. Alexinschi O. Ifteni P. Turliuc S. Ciuhodaru T. Bolos A. Matei V. Nieman D.H. Sommer I. van Os J. van Amelsvoort T. Sun C.-F. Guu T.-W. Jiao C. Zhang J. Fan J. Zou L. Yu X. Chi X. de Timary P. van Winkel R. Ng B. Pena E. Arellano R. Roman R. Sanchez T. Movina L. Morgado P. Brissos S. Aizberg O. Mosina A. Krinitski D. Mugisha J. Sadeghi-Bahmani D. Sheybani F. Sadeghi M. Hadi S. Brand S. Errazuriz A. Crossley N. Ristic D.I. López-Jaramillo C. Efthymiou D. Kuttichira P. Kallivayalil R.A. Javed A. Afridi M.I. James B. Seb-Akahomen O.J. Fiedorowicz J. Daskalakis J. Yatham L.N. Yang L. Okasha T. Dahdouh A. Tiihonen J. Shin J.I. Lee J. Mhalla A. Gaha L. Brahim T. Altynbekov K. Negay N. Nurmagambetova S. Jamei Y.A. Weiser M. Correll C.U.
April 2025Elsevier Inc.
Journal of the American Academy of Child and Adolescent Psychiatry
2025#64Issue 4499 - 519 pp.
Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide. Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization–Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori– defined individual/cumulative risk factors were measured. A χ2, penalized cubic splines, linear regression, and correlation analyses were conducted. Results: Analyzing 8,115 of 8,762 initiated surveys (representative = 75.1%), the pre-pandemic WHO-5 and P-score remained stable during the study (excluding relevant recall bias/drift), but worsened during the pandemic by 5.55 ± 17.13 (SD) and 6.74 ± 16.06 points, respectively (effect size d = 0.27 and d = 0.28). The proportion of adolescents with WHO-5 scores suggesting depression screening (<50) and major depression (<29) increased from 9% to 17% and 2% to 6%. WHO-5 worsened (descending magnitude, with cumulative effect) in adolescents with a mental or physical disorder, female gender, and with school closure. Results were similar for the P-score, with the exception of school closure (not significant) and living in a low-income country, as well as not living in a large city (significant). Changes were significantly but minimally related to COVID-19 deaths/restrictions, returning to near–pre-pandemic values after >2 years. The 3 most subjectively effective coping strategies were Internet use, exercise/walking, and social contacts. Conclusion: Overall, well-being/mental health worsened (small effect sizes) during the early stages of the COVID-19 pandemic, especially in vulnerable subpopulations. Identified at-risk groups, association with pandemic-related measures, and coping strategies can inform individual behaviors and global public health strategies. Plain language summary: The impact of COVID-19 and related restrictions on the mental health of children and adolescents remains unclear. This study conducted an anonymous online survey with over 8,100 adolescents aged 14 to 17 years worldwide. Results showed a significant decline in wellbeing, with depression rates increasing from 9% to 17% returning to near- pre-pandemic values after about 2 years. Adolescents with preexisting mental health conditions, female youth, and those affected by school closures were particularly vulnerable. Effective coping strategies included internet use, exercise, and social contacts, highlighting areas for public health focus to support youth during pandemics. Study preregistration information: Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A); https://doi.org/10.1016/j.jad.2021.09.090 Diversity & Inclusion Statement: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. We actively worked to promote sex and gender balance in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science.
COVID-19 , p-factor , pandemic , survey , well-being , WHO-5
Text of the article Перейти на текст статьи
University of Ottawa and The Ottawa Hospital, Ottawa, Canada
Ottawa Hospital Research Institute (OHRI), Ottawa, Canada
Kings College London, London, United Kingdom
University of Southampton, Southampton, United Kingdom
Charité Universitätsmedizin Berlin, Berlin, Germany
University of Greenwich, London, United Kingdom
Universidad Católica del Uruguay, Montevideo, Uruguay
Aristotle University of Thessaloniki, Thessaloniki, Greece
University of Barcelona, Barcelona, Spain
Karolinska Institutet in Stockholm, Sweden
Linköping University, Linköping, Sweden
University of Ioannina, Ioannina, Greece
Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
University of Southern Denmark, Denmark
BioPsyC - Biopsychosocial Corporation, Vienna, Austria
University of California San Diego, CA, United States
University of Basel, Basel, Switzerland
Universitäre Psychiatrische Kliniken Basel (UPK), Basel, Switzerland
University of Fribourg, Fribourg, Switzerland
University of Lausanne, Lausanne, Switzerland
University of Zurich, Switzerland
University of Navarra in Pamplona, Spain
South London and Maudsley NHS Foundation Trust, London, United Kingdom
University of Pavia, Pavia, Italy
Université Paris Cité, Paris, France
Institute de Psychiatrie et Neuroscience de Paris, Paris, France
Université Clermont Auvergne, Clermont-Ferrand, France
Université de Paris, Paris, France
Keio University in Tokyo, Tokyo, Japan
National Foundation of Mental Health of Bangladesh, Bangladesh
Pomeranian Medical University in Szczecin, Szczecin, Poland
University of Milan, Milan, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
University of Padua, Padua, Italy
UOC Infanzia, Adolescenza, Famiglia e Consultori, Verona, Italy
University of Udine, Italy
GHNE, France
Medical University of Białystok, Bialystok, Poland
Kharazmi University, Tehran, Iran
Stellenbosch University, South Africa
South East Technological University in Waterford, Ireland
University of Nicosia, Nicosia, Cyprus
Universidade Federal de São Paulo, São Paulo, Brazil
An-Nan Hospital in Tainan, Taiwan
China Medical University Hospital in Taichung, Taiwan
Seoul National University College of Medicine, Seoul, South Korea
Seoul National University Hospital, Seoul, South Korea
Pusan National University Yangsan Hospital, Yangsan, South Korea
Moscow Research Institute of Psychiatry, Moscow, Russian Federation
National Institute of Mental Health in Klecany, Czech Republic
UTHealth in Houston, United States
AULSS4 Veneto Orientale, Italy
University of Modena and Reggio Emilia in Modena, Italy
ASL Salerno and the European Biomedical Research Institute of Salerno (EBRIS) in Salerno, Italy
University of Padova, Padova, Italy
University of Palermo, Palermo, Italy
Azienda Ospedaliero-Universitaria Ss
Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
Technische Universität Dresden, Dresden, Germany
Heidelberg University, Germany
Hannover Medical School, Germany
University of Freiburg, Freiburg, Germany
Ludwig-Maximilians-University of Munich, Munich, Germany
University of Lübeck, Lübeck, Germany
Semmelweis University, Budapest, Hungary
Eotvos Lorand University, Budapest, Hungary
Bjørknes University College, Oslo, Norway
Chulalongkorn University, Thailand
Universidade de São Paulo, São Paulo, Brazil
Universidade Federal de Santa Maria, RS, Santa Maria, Brazil
Universidad Autónoma de Chile, Providencia, Chile
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Universidade do Extremo Sul Catarinense, SC, Criciúma, Brazil
University of Copenhagen, Copenhagen, Denmark
Psykiatrifonden, Copenhagen, Denmark
Le Jolimont Psychiatry and Psychotherapy, Fribourg, Switzerland
Association for the Improvement of Mental Health Programmes (AMH), Switzerland
FHNW University of Applied Sciences and Arts Northwestern Switzerland, Switzerland
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, United States
Universitat Autònoma de Barcelona, Barcelona, Spain
University of Texas Health Science Center, Houston, United States
Zucker Hillside Hospital, Northwell Health, and the Feinstein Institutes for Medical Research, New York
S2 Consulting LLC
Parc Sanitari Sant Joan de Déu, Barcelona, Spain
Hospital General Universitario Gregorio Marañón, Madrid, Spain
Mental Health Center of Perugia, Italy
Glasgow University, Glasgow, United Kingdom
Sanprobi Sp. z o.o. Sp. k, Poland
University of Białystok, Białystok, Poland
Centre for Digestive Diseases Endoklinika, Szczecin, Poland
University of Manchester, United Kingdom
University of Bristol, Bristol, United Kingdom
Istanbul Topkapı University, Istanbul, Turkey
Adnan Menderes University Department of Child and Adolescent Psychiatry, Aydın, Turkey
Uskudar University, Istanbul, Turkey
Griffith University, South East Queensland, Australia
Mindgardens Neuroscience Network, Sydney, Australia
Deakin University, Victoria, Australia
UNSW Sydney, Sydney, Australia
University of Medicine and Pharmacy Grigore T. Popa, Iasi, Romania
Institute of Psychiatry “Socola”, Iasi, Romania
Transilvania University of Brasov, Brasov, Romania
Emergency Hospital “Nicolae Oblu”, Iasi, Romania
University of Medicine and Pharmacy “Carol Davila” Bucharest, Bucharest, Romania
Amsterdam University Medical Centers, Amsterdam, Netherlands
University Medical Center Groningen, Groningen, Netherlands
Utrecht University Medical Centre, Utrecht, Netherlands
Maastricht University, Maastricht, Netherlands
Carilion Clinic Virginia Tech Carilion School of Medicine, Roanoke, VA, United States
China Medical University Beigang Hospital, Taiwan
Shenzhen University, Shenzhen, China
Peking University Institute of Mental Health, Pekin, China
UCLouvain, Brussels, Belgium
Cliniques Universitaires Saint-Luc, Brussels, Belgium
Asociación Psiquiátrica Mexicana, Mexico
University of Minho, Braga/Guimarães, Portugal
ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal
Lisbons Psychiatric Hospital Centre, Portugal
Belarusian Medical Academy of Postgraduate Education, Belarus
Clienia AG, Switzerland
Integrated Psychiatry Winterthur (IPW), Switzerland
Kyambogo University, Kampala, Uganda
Stanford University, CA, United States
Mashhad University of Medical Sciences, Mashhad, Iran
Kermanshah University of Medical Sciences, Kermanshah, Iran
Psychiatric Clinics of the University of Basel, Basel Switzerland
Tehran University of Medical Sciences, Tehran, Iran
Pontificia Universidad Católica de Chile, Santiago, Chile
University of Kragujevac, Kragujevac, Serbia
University of Antioquia, Medellín, Colombia
Nous Therapy Center, Thessaloniki, Greece
Jubilee Mission Medical College & Research Institute, Thrissur, India
Pushpagiri Institute of Medical Sciences, Thiruvalla, Kerala, India
Pakistan Psychiatric Research Centre-Fountain House, Lahore, Pakistan
Faculty of Psychiatry, College of Physicians and Surgeons, Jinnah Postgraduate Medical Centre, and Jinnah Sindh Medical University in Karachi, Pakistan
Tees Esk & Wear Valleys NHS Foundation Trust, United Kingdom
Irrua Specialist Teaching Hospital, Edo State, Nigeria
UC San Diego, CA, United States
University of British Columbia, Vancouver, Canada
Alberta Health Services and the University of Calgary, Calgary, Canada
Ain Shams University, Cairo, Egypt
Ora University, Oran, Algeria
University of Eastern Finland, Kuopio, Finland
Yonsei University College of Medicine, Seoul, South Korea
Wonju College of Medicine, Wonju, South Korea
University of Monastir, Monastir, Tunisia
Republican Scientific and Practical Center of Mental Health, Almaty, Kazakhstan
Gaza Community Mental Health Programme, Gaza, Palestine
Sheba Medical Center, Israel
University of Ottawa and The Ottawa Hospital
Ottawa Hospital Research Institute (OHRI)
Kings College London
University of Southampton
Charité Universitätsmedizin Berlin
University of Greenwich
Universidad Católica del Uruguay
Aristotle University of Thessaloniki
University of Barcelona
Karolinska Institutet in Stockholm
Linköping University
University of Ioannina
Katholieke Universiteit Leuven (KU Leuven)
University of Southern Denmark
BioPsyC - Biopsychosocial Corporation
University of California San Diego
University of Basel
Universitäre Psychiatrische Kliniken Basel (UPK)
University of Fribourg
University of Lausanne
University of Zurich
University of Navarra in Pamplona
South London and Maudsley NHS Foundation Trust
University of Pavia
Université Paris Cité
Institute de Psychiatrie et Neuroscience de Paris
Université Clermont Auvergne
Université de Paris
Keio University in Tokyo
National Foundation of Mental Health of Bangladesh
Pomeranian Medical University in Szczecin
University of Milan
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
University of Padua
UOC Infanzia
University of Udine
GHNE
Medical University of Białystok
Kharazmi University
Stellenbosch University
South East Technological University in Waterford
University of Nicosia
Universidade Federal de São Paulo
An-Nan Hospital in Tainan
China Medical University Hospital in Taichung
Seoul National University College of Medicine
Seoul National University Hospital
Pusan National University Yangsan Hospital
Moscow Research Institute of Psychiatry
National Institute of Mental Health in Klecany
UTHealth in Houston
AULSS4 Veneto Orientale
University of Modena and Reggio Emilia in Modena
ASL Salerno and the European Biomedical Research Institute of Salerno (EBRIS) in Salerno
University of Padova
University of Palermo
Azienda Ospedaliero-Universitaria Ss
Antonio e Biagio e Cesare Arrigo
Technische Universität Dresden
Heidelberg University
Hannover Medical School
University of Freiburg
Ludwig-Maximilians-University of Munich
University of Lübeck
Semmelweis University
Eotvos Lorand University
Bjørknes University College
Chulalongkorn University
Universidade de São Paulo
Universidade Federal de Santa Maria
Universidad Autónoma de Chile
Federal University of Rio de Janeiro
Universidade do Extremo Sul Catarinense
University of Copenhagen
Psykiatrifonden
Le Jolimont Psychiatry and Psychotherapy
Association for the Improvement of Mental Health Programmes (AMH)
FHNW University of Applied Sciences and Arts Northwestern Switzerland
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Universitat Autònoma de Barcelona
University of Texas Health Science Center
Zucker Hillside Hospital
S2 Consulting LLC
Parc Sanitari Sant Joan de Déu
Hospital General Universitario Gregorio Marañón
Mental Health Center of Perugia
Glasgow University
Sanprobi Sp. z o.o. Sp. k
University of Białystok
Centre for Digestive Diseases Endoklinika
University of Manchester
University of Bristol
Istanbul Topkapı University
Adnan Menderes University Department of Child and Adolescent Psychiatry
Uskudar University
Griffith University
Mindgardens Neuroscience Network
Deakin University
UNSW Sydney
University of Medicine and Pharmacy Grigore T. Popa
Institute of Psychiatry “Socola”
Transilvania University of Brasov
Emergency Hospital “Nicolae Oblu”
University of Medicine and Pharmacy “Carol Davila” Bucharest
Amsterdam University Medical Centers
University Medical Center Groningen
Utrecht University Medical Centre
Maastricht University
Carilion Clinic Virginia Tech Carilion School of Medicine
China Medical University Beigang Hospital
Shenzhen University
Peking University Institute of Mental Health
UCLouvain
Cliniques Universitaires Saint-Luc
Asociación Psiquiátrica Mexicana
University of Minho
ICVS/3Bs - PT Government Associate Laboratory
Lisbons Psychiatric Hospital Centre
Belarusian Medical Academy of Postgraduate Education
Clienia AG
Integrated Psychiatry Winterthur (IPW)
Kyambogo University
Stanford University
Mashhad University of Medical Sciences
Kermanshah University of Medical Sciences
Psychiatric Clinics of the University of Basel
Tehran University of Medical Sciences
Pontificia Universidad Católica de Chile
University of Kragujevac
University of Antioquia
Nous Therapy Center
Jubilee Mission Medical College & Research Institute
Pushpagiri Institute of Medical Sciences
Pakistan Psychiatric Research Centre-Fountain House
Faculty of Psychiatry
Tees Esk & Wear Valleys NHS Foundation Trust
Irrua Specialist Teaching Hospital
UC San Diego
University of British Columbia
Alberta Health Services and the University of Calgary
Ain Shams University
Ora University
University of Eastern Finland
Yonsei University College of Medicine
Wonju College of Medicine
University of Monastir
Republican Scientific and Practical Center of Mental Health
Gaza Community Mental Health Programme
Sheba Medical Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026