Positive Effect of Platelet-Rich Plasma on Neoureterocystostomy in Rats: An Experimental Study
Smagulov A. Rysmakhanov M. Sultangereyev Y. Karakaya E. Akdur A. Uysal A.C. Borcek P. Mussin N. Haberal M.
January 2023Baskent University
Experimental and Clinical Transplantation
2023#21Issue 147 - 51 pp.
Objectives: Some of the most common problems after kidney transplant are urologic complications, including ureterocystoanastomosis leakage and stenosis with the development of severe renal graft complicationsIsolated plasma contains active substances that cause the activation of various growth factors for the processes of tissue repair or regeneration, has an antiinflam-matory effect, activates angiogenesis, and reduces the risk of infectious complications. Platelet-rich plasma is actively used to stimulate bone regeneration, heawounds and ulcers on the skin, enhance reconstruction of the larynx and trachea, and ameliorate urethradamage, among other uses. This study was developed to evaluate the positive effect of platelet-rich plasma on the healing process of an anastomotic wound in a model of ureterocystoanas-tomosis in rats. Material and Methods: We randomized 14 Wistar albino male rats into 2 groups: group 1 included 7 rats that received platelet-rich plasma after ureterocystostomygroup 2 was the control group and included 7 rats that underwent ureterocystostomy without platelet-rich plasma. On postoperative day 7, all animals were euthanized, and the anastomosis area was resected for determination of the tissue hydroxyproline levels and histopathology examination. Results: Tissue hydroxyproline levels were 767 ± 62.9 μg/g in group 1 and 256 ± 28.0 μg/g in group 2. Tissue hydroxyproline levels were significantly higher in group 1 compared with group 2 (P < .05). There were no significant differences in epithelial damage, acute inflammation, or fibrosis between the tissue samples of both groups. Conclusions: The results of this study show that the use of platelet-rich plasma during ureterocystostomy produces a positive effect. Our further research will be devoted to the use of autologous platelet-rich plasma in ureterocystostomy in big models.
Kidney transplant , Ureterocystoanastomosis , Ureterocystostomy , Ureteroneocystostomy , Urologic complications
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Department of Surgery 2, West-Kazakhstan Medical University, Aktobe, Kazakhstan
Department of Surgery and Transplantation, Aktobe Medical Center, Aktobe, Kazakhstan
Department of General Surgery, Division of Transplantation, Baskent University, Turkey
Department of Medical Pathology, Faculty of Medicine, Ankara, Turkey
Department of Surgery 2
Department of Surgery and Transplantation
Department of General Surgery
Department of Medical Pathology
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