Genetic Variants in Preeclampsia During Pregnancy: A Hospital-Based Case–Control Study

Slobodchikova T. Tayzhanova D. Amirbekova Z. Vazenmiller D. Mustafin R. Izmailovich M.
June 2025 Multidisciplinary Digital Publishing Institute (MDPI)

Journal of Clinical Medicine
2025 #14 Issue 11

Background/Objectives: Preeclampsia is a multifactorial disorder with a possible genetic component. While numerous studies have explored genetic susceptibility, validation remains inconsistent. The aim was to assess the association between hypertension-related polymorphisms and preeclampsia risk. Methods: A case–control study was conducted in Karaganda, Kazakhstan (n = 95). Sixty SNPs were genotyped using the QuantStudio™ 12K Flex system. Genotype–phenotype associations were evaluated using five inheritance models and statistical analysis in R. Results: Significant associations were found for rs2516839 (C/T: OR = 5.28; 95% CI: 1.53–18.15), rs17672135 (T/T: OR = 3.48; CI: 1.05–11.5), and rs10757278 (A/G: OR = 0.3; CI: 0.11–0.83). However, wide confidence intervals suggest potential limitations in sample size and generalizability. Conclusions: While these polymorphisms show promise as genetic markers of preeclampsia risk, their clinical application requires further validation in larger, multi-ethnic cohorts.

genetic polymorphisms , genotype–phenotype association , hypertensive complications , preeclampsia , reproductive health risks

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Department of Obstetrics, Gynecology and Perinatology, Karaganda Medical University, Karaganda, 100000, Kazakhstan
Department of Internal Diseases, Karaganda Medical University, Karaganda, 100000, Kazakhstan
EcoLife Clinic, Astana, 010000, Kazakhstan

Department of Obstetrics
Department of Internal Diseases
EcoLife Clinic

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