Serotype dynamics of Streptococcus pneumoniae in some countries in Eastern Europe and Central Asia
Sidorenko S.V. Rennert W. Zhdanov K.V. Lobzin Y.V. Nikitina E.V. Ageevets V.A. Martens E.A. Rybalko D.S. Kalinogorskaya O.S. Goncharova A.R. Goncharov N.E. Tsvetkova I.A. Kraeva L.A. Zhimbayeva O.B. Andreeva A.N. Ardysheva A.T. Bayazitova L.T. Beissegulova G.N. Bikmieva A.V. Bolgarova E.V. Brzhozovskaya E.A. Burkutbayeva T.N. Feldblum I.V. Girina A.A. Gordeeva S.A. Hanenko O.N. Illarionova T.V. Sh. Isaeva G. Klimashina A.V. Kolomiets N.D. Koloskova Y.A. Kovalishena O.V. Kozeeva T.G. Mayanskiy N.A. Mustafina K.K. Nemirovchenko I.A. Petrova L.Y. Pozdeeva I.V. Ramazanova B.A. Romanova O.N. Salina V.A. Seitkhanova B.T. Shirokova I.Y. Sokolova N.V. Tomracheva L.V. Tonko O.V. Tyurin Y.A. Venchakova V.V. Verentsova I.V. Yeraliyeva L.T. Zakharova Y.A.
31 May 2025Elsevier Ltd
Vaccine
2025#57
The burden of pneumococcal disease remains a global challenge. The purpose of this work was to assess the serotype composition of S. pneumoniae circulating among children under 5 years of age in Eastern European (the Russian Federation and the Republic of Belarus) and Central Asian (the Republic of Kazakhstan) countries which are characterized by close cultural and economic ties. The most pronounced changes were noted in the Russian Federation. In the pre-vaccination period (before 2015) PCV13 covered 66 % - 90 % of prevalent serotypes. In 2016–2018 coverage decreased to 59.2 %. During this study period (2020−2023) PCV 13 related serotypes in healthy children and those with respiratory infections dropped further to 23.2 % and 35.7 %, respectively. In Kazakhstan, vaccine-related serotypes among healthy children and children with RTI were more prevalent than in Russia (51.5–58.6 % vs 23.2–35.7 %) despite both countries having introduced pneumococcal vaccination at the same time, and both countries reporting vaccination rates above 90 % in children under 5 years of age. In the Republic of Belarus, in the absence of a universal vaccination program, PCV13 covers 86.4 % of serotypes. Serotypes 19F (31 %), 3 (16.2 %), 19 A (10.3 %), and 14 (10 %) predominate among S. pneumoniae causing acute otitis media in children. Expanding the serotype/serogroup composition of new vaccines may provide protection against potentially invasive non-vaccine strains in the future.
Invasive pneumococcal disease , Pneumococcal vaccination , Russian Federation , Serotypes , Streptococcus pneumoniae
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Pediatric Research and Clinical Center for Infectious Diseases, North-Western State Medical University named after I. I. Mechnikov, Kirochnaya Ulitsa, 41, St Petersburg, 191015, Russian Federation
Rostropovich Vishnevskaya Foundation, 1717 K Street, N.W., Suite 900, Washington, 20006, DC, United States
Georgetown University Hospital Department of Pediatrics, 4200 Wisconsin Ave, NW, Suite 200, Washington, 20016, DC, United States
Saint-Petersburg Pasteur Institute, Ulitsa Mira, 14, St Petersburg, 197101, Russian Federation
St. Petersburg State Pediatric Medical University, Litovskaya Ulitsa, 2, St Petersburg, 194100, Russian Federation
Military Medical Academy named after S.M. Kirov, 6, Academika Lebedeva Street, St Petersburg, 194044, Russian Federation
Perm Clinical Center of the Federal Medical and Biological Agency, Tselinnaya Str, 27, Perm, 614056, Russian Federation
Kazan Scientific Research Institute of Epidemiology and Microbiology, Kazan State Medical University named after Academician V.M. Aristovsky, Butlerova Str, 49, Kazan, 420012, Russian Federation
Asfendiyarov Kazakh National Medical University, Tole Bi Str, 94, Almaty, 050000, Kazakhstan
E.A.Vagner Perm State Medical University, Ulitsa Kuybysheva, 39, Perm, 614000, Russian Federation
Federal Scientific Research Institute of Viral Infections “Virome”, Letnaya Str, Ekatarinburg, 620030, Russian Federation
Russian Childrens Clinical Hospital of Pirogov Russian National Research Medical University, Ulitsa Taldomskaya, 2, Moscow, 125412, Russian Federation
Khanty-Mansiysk State Medical Academy, Ulitsa Mira, 40, Khanty-Mansiysk, Khanty-Mansiyskiy Avtonomnyy Okrug, 628011, Russian Federation
Clinical Infectious Diseases Hospital named after S.P. Botkin, Piskaryovskiy Avenue, 49, St Petersburg, 195067, Russian Federation
Belarusian State Medical University, Prospekt Dzerzhinskogo 83, Minskaja Voblasc, Minsk, 220116, Belarus
Privolzhsky Research Medical University, Minin and Pozharsky Sq, 10/1, Nizhny Novgorod, Nizhny Novgorod Oblast, 603005, Russian Federation
District Clinical Hospital of the Khanty-Mansiysk Autonomous Okrug – Ugra, Barabinskaya Ulitsa, 12, Khanty-Mansiysk, Khanty-Mansiyskiy avtonomnyy okrug, 628001, Russian Federation
South Kazakhstan Medical Academy, Al-Farabi Square 1, Shymkent, 160001, Kazakhstan
National Academy of Sciences under the President of the Republic of Kazakhstan, 28 Shevchenko Str, Almaty, 050010, Kazakhstan
F.F. Erisman Federal Scientific Centre of Hygiene Rospotrebnadzor, Semashko Str, 2, Moscow, 141000, Russian Federation
Pediatric Research and Clinical Center for Infectious Diseases
Rostropovich Vishnevskaya Foundation
Georgetown University Hospital Department of Pediatrics
Saint-Petersburg Pasteur Institute
St. Petersburg State Pediatric Medical University
Military Medical Academy named after S.M. Kirov
Perm Clinical Center of the Federal Medical and Biological Agency
Kazan Scientific Research Institute of Epidemiology and Microbiology
Asfendiyarov Kazakh National Medical University
E.A.Vagner Perm State Medical University
Federal Scientific Research Institute of Viral Infections “Virome”
Russian Childrens Clinical Hospital of Pirogov Russian National Research Medical University
Khanty-Mansiysk State Medical Academy
Clinical Infectious Diseases Hospital named after S.P. Botkin
Belarusian State Medical University
Privolzhsky Research Medical University
District Clinical Hospital of the Khanty-Mansiysk Autonomous Okrug – Ugra
South Kazakhstan Medical Academy
National Academy of Sciences under the President of the Republic of Kazakhstan
F.F. Erisman Federal Scientific Centre of Hygiene Rospotrebnadzor
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