Association of Polymorphism rs2736990 of the α-Synuclein Gene with Metabolic Syndrome Among the Population of Kazakhstan with Arterial Hypertension
Sibagatova A. Benberin V. Akhmetova K. Babenko D. Karabayeva R.
22 May 2024Mary Ann Liebert Inc.
Metabolic Syndrome and Related Disorders
2024#22Issue 4263 - 268 pp.
Background: The prevalence of metabolic syndrome (MetS) in Kazakhstan reaches 40%. The presence of an association between certain genetic markers and the development of MetS will allow more accurately determining the cardiovascular risk for patients with hypertension and personalizing preventive recommendations. Methods: The purpose of the study was to investigate the presence of an associative relationship between various polymorphisms of the α-synuclein gene and the development of MetS in Kazakh people with high blood pressure. Four hundred twenty-six patients were examined [age 49.5 (interquartile range 42.5-56), men 209 (49.1%), women 217 (50.9%)]. Standard clinical and laboratory methods were used. AutoMate Express™ and OpenArray technologies were used for DNA extraction and further genotyping. Patients with MetS made up the ms+ group, those without MetS—the ms− group. Results: In the examined patients, four polymorphisms of the α-synuclein gene were identified: rs356219, rs2736990, rs11931074, and rs2737029. According to the results of statistical analysis, the frequency and risk of developing MetS did not depend on different alleles and inheritance types of polymorphisms rs356219 and rs11931074. The minor allele of polymorphism rs2737029 exhibits a higher frequency in patients with arterial hypertension accompanied by MetS, although the specific model of inheritance remains to be conclusively determined. Conclusions: In carriers of the minor allele of polymorphism rs2736990, the risk of MetS increases 1.3 times, regardless of age and gender [odds ratio (95% confidence interval) = 1.36 (1.01-1.82), P < 0.05], the inheritance model is log-additive. Copyright 2024, Mary Ann Liebert, Inc., publishers.
abdominal obesity , dyslipidemia , genetics , high blood pressure , hyperglycemia
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Department of Science and Gerontology, Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Biology, Karaganda Medical University, Karaganda, Kazakhstan
Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Department of Science and Gerontology
Asfendiyarov Kazakh National Medical University
Department of Biology
Medical Centre Hospital of Presidents Affairs Administration of the Republic of Kazakhstan
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