Flavonoid glycosides in Lepidium sativum seeds and their bioactivities
Shybyray Y. Liu L. Zhao H. Li J. Aisa H.A.
May 2025Elsevier Ltd
Phytochemistry
2025#233
Twelve flavonoid glycosides including five undescribed ones, lepisativutimines Q−U, were isolated and identified from Lepidium sativum seeds. Acid hydrolysis followed by acetic derivatization and GC analysis were conducted to determine the absolute configurations for sugars. Lepisativutimine U and beitingxinhuangtong A were uncommon kaempferol 8-S-glycosides, and complete NMR data of beitingxinhuangtong A were provided for the first time. Mass fragmentation pathways of isolated compounds were deduced based on their MS/MS data, and characteristic mass fragmentation patterns were summarized. Lepisativutimine U and kaempferol-7-O-α-L-rhamnopyranoside exhibited weak anti-diabetic activity against PTP1B with IC50 values of 60.58 ± 3.53 and 33.90 ± 2.89 μM, respectively, quercetin-7-O-α-L-rhamnopyranoside displayed significant anti-diabetic activity against α-glucosidase with an IC50 value of 25.96 ± 0.30 μM, and kaempferol 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside and kaempferol-7-O-α-L-rhamnopyranoside showed weak inhibitory activity against NO release in LPS-induced RAW264.7 cells with IC50 values of 92.28 ± 4.19 and 40.77 ± 1.50 μM, respectively.
Activity , Brassicaceae , Flavonoid glycosides , Isolation and structural identification , Lepidium sativum seeds , Mass fragmentation pathway
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State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Xinjiang, Urumqi, 830011, China
University of Chinese Academy of Sciences, Beijing, 100039, China
College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China
The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabiave. 71, Almaty, 050040, Kazakhstan
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plants Resources and Chemistry of Arid Zone
University of Chinese Academy of Sciences
College of Pharmacy
The Research Center for Medicinal Plants
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