Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols

Modelado del Daño Agudo y Subagudo Cruzado Mediado al Sistema Pulmonar Durante la Infección Sistémica (Subcutánea) de Administración de Bleomicina a Ratones para Probar el Posible Efecto Terapéutico de los Polifenoles
Shulgau Z. Kamyshanskiy Y. Sergazy S. Zhulikeyeva A. Urazbayeva A. Makhmutova A. Bokebayev Z. Gulyayev A. Ramankulov Y.
Dec 2023 Universidad de la Frontera

International Journal of Morphology
2023 #41 Issue 6 1837 - 1845 pp.

SUMMARY: The potential anti-inflammatory and antifibrotic activity of polyphenolic extracts of blueberry and grape was evaluated in a mouse model of lung damage induced by subcutaneous administration of bleomycin. The results of testing the polyphenolic extracts on two different systemic administration variants of bleomycin (intraperitoneal and subcutaneous) were compared. It was found that regardless of the method of bleomycin administration, indirect cross-acute and subacute damage to the pulmonary system was observed. Both patterns exhibited the same prevalence and severity. The administration of polyphenolic extracts of blueberry and grape to mice resulted in a significant decrease in theseverity of acute and subacute patterns of lung damage, suggesting their protective properties for the microcirculatory bed and a pronounced anti-inflammatory effect.

Bleomycin , Blueberry extract , Fibrosis , Grape extract , Polyphenols

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National Center for Biotechnology, Kurgalzhynskoye Road 13/5, Astana, Kazakhstan
Clinic of Medical University MUK NCJSC, Ardak Str. 3, Karaganda, Kazakhstan
National Laboratory Astana, Nazarbayev University, Kabanbai Batyr Ave. 53, Astana, Kazakhstan
Research Institute of Balneology and Medical Rehabilitation, Kenesary Str. 1, Burabay village, Burabaysky district, Akmola region, Kazakhstan
NpJSC «Astana Medical University», Beibitshilik Str. 49a, Astana, Kazakhstan
School of Humanities and Social Sciences, Nazarbayev University, Kabanbai Batyr Ave. 53, Astana, Kazakhstan

National Center for Biotechnology
Clinic of Medical University MUK NCJSC
National Laboratory Astana
Research Institute of Balneology and Medical Rehabilitation
NpJSC «Astana Medical University»
School of Humanities and Social Sciences

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