Characteristics of the pregnancy and labour course in women who underwent COVID-19 during pregnancy

Shukenova E. Minkauskiene M. Dzhardemalieva N. Koshenova L. Ospanova S.
1 February 2025 Walter de Gruyter GmbH

Journal of Perinatal Medicine
2025 #53 Issue 2 205 - 212 pp.

Objectives: This study aims to analyze the impact of COVID-19 on pregnancy and labor, focusing on its effects on maternal and child health. The research explores the relationships between coronavirus infection and clinical and laboratory parameters, as well as the risks of pregnancy complications and adverse birth outcomes. Methods: The study involved 60 pregnant women diagnosed with COVID-19. A comprehensive evaluation of clinical and laboratory indicators was conducted, employing correlation, regression, logistic analyses to determine risk factors. Results: There was a strong inverse correlation between carbon dioxide levels and haematocrit (−0.76), and a direct correlation between blood pH and partial pressure of oxygen (0.73). COVID-19 was associated with increased risks of preterm labor (OR=1.82), stillbirth (OR=2.11), pre-eclampsia (OR=1.46), and foetal distress. Multivariate analysis revealed a 200 g reduction in neonatal birth weight and higher risks of hospitalisation (OR=1.8), postpartum hemorrhage (OR=2.3), and preterm delivery (OR=2.5). Comorbid conditions such as cardiovascular abnormalities, diabetes, obesity, thrombophilias exacerbated the risks of complications, including pre-eclampsia, neonatal respiratory distress syndrome, venous thromboembolism. Conclusions: COVID-19 infection increases the likelihood of pregnancy complications and adverse outcomes, especially in women with comorbidities. These findings highlight the need for preventive strategies and risk management protocols for pregnant women during future outbreaks, emphasizing the importance of further research in this field.

coronavirus infection , foetal distress , pre-eclampsia , preterm labour , stillbirth

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Department of Epidemiology, Evidence-Based Medicine and Biostatistics, Kazakhstan Medical University, “Kazakhstan School of Public Health”, 050060, 19A Utepov Str., Almaty, Kazakhstan
Department of Obstetrics and Gynaecology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Department of Obstetrics and Gynaecology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Department of Epidemiology
Department of Obstetrics and Gynaecology
Department of Obstetrics and Gynaecology

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